Asian Pacific Journal of Cancer Prevention
- Volume 17 Issue 11
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- Pages.4907-4911
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- 2016
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- 1513-7368(pISSN)
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- 1513-7368(eISSN)
DOI QR Code
Evaluation of JC and Cytomegalo Viruses in Glioblastoma Tissue
- Afshar, Reza Malekpour (Research Center for Tropical and Infectious Disease) ;
- Mollaei, Hamid Reza (Department of Medical Microbiology, Kerman University of Medical Sciences) ;
- Zandi, Bahare (Research Center for Tropical and Infectious Disease) ;
- Iranpour, Maryam (Department of Pathology and Stem Cell Research Center, Kerman University of Medical Sciences)
- Published : 2016.11.01
Abstract
Glioblastoma multiforme (GBM) is the most aggressive of the gliomas, a collection of tumors arising from glia in the central nervous system. Possible associations between the human cytomegalovirus (HCMV) and the JC virus with GBM are now attracting interest. Our present aim was to investigate the prevalence of the two viruses in Iranian patients from Kerman's cities in the south of Iran. In addition, the expression rates of pp65, large T antigen and p53 proteins were assessed and their relation with GBM evaluated using reverse transcription real time PCR (rReal Time PCR). A total of 199 patients with GBM cancer were enrolled, with
Keywords
Glioblastoma;HCMV;JC Virus;P53;large T Antigen
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