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Improved Survival of Cervical Cancer Patients in a Screened Population in Rural India

  • Jayant, Kasturi (Nargis Dutt Memorial Cancer Hospital) ;
  • Sankaranarayanan, Rengaswamy (Early Detection and Prevention Section and Screening Group, World Health Organization -International Agency for Research on Cancer (WHO-IARC)) ;
  • Thorat, Ranjit V (Nargis Dutt Memorial Cancer Hospital) ;
  • Muwonge, Richard (Early Detection and Prevention Section and Screening Group, World Health Organization -International Agency for Research on Cancer (WHO-IARC)) ;
  • Hingmire, Sanjay J (Nargis Dutt Memorial Cancer Hospital) ;
  • Panse, Nandkumar S (Nargis Dutt Memorial Cancer Hospital) ;
  • Shastri, Surendra S (Department of Preventive Oncology, Tata Memorial Center, Tata Memorial Hospital and Cancer Research Institute) ;
  • Malvi, Sylla G (Nargis Dutt Memorial Cancer Hospital) ;
  • Nene, Bhagwan (Nargis Dutt Memorial Cancer Hospital)
  • Published : 2016.11.01

Abstract

Objectives: To describe the survival experience of cervix cancer patients in a screened rural population in India. Methods: Included 558 cervical cancer patients diagnosed in 2000-2013 in a cohort of 100,258 women invited for screening during 2000-2003. The primary end point was death from cervical cancer. We used the Kaplan-Meier method to estimate cumulative observed survival and Cox proportional hazards regression to assess the effect of patient characteristics on survival after diagnosis. Results: Of the 558 cases included, 143 (26%) and 114 (20%) were diagnosed in stages IA and IB respectively; 252 (45.2%) were dead, and 306 (54.8%) were alive at the last follow-up. The overall 5-year observed survival was 60.5%. The 5-year survival of stage IA patients was 95.1% and 5.3% for stage IV patients. All surgically treated stage IA patients, 94.1% of stage IB patients receiving intracavitary radiotherapy, 62% of stage IIB, 49% of stage III and 25% of stage IV patients receiving radiotherapy survived for 5 years. Conclusion: Higher 5-year survival in our study than elsewhere in India is due to the high proportion of early stage cancers detected by screening combined with adequate treatment, resulting into a favourable prognosis.

Keywords

Survival;cervical cancer;developing countries

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