- Volume 17 Issue 10
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High Mortality Rate of Stomach Cancer Caused Not by High Incidence but Delays in Diagnosis in Aomori Prefecture, Japan
- Matsuzaka, Masashi (Department of Medical Informatics, Hirosaki University Hospital) ;
- Tanaka, Rina (Department of Medical Informatics Hirosaki University Graduate School of Medicine) ;
- Sasaki, Yoshihiro (Department of Medical Informatics, Hirosaki University Hospital)
- Published : 2016.10.01
Background: There are substantial differences in the mortality rates of stomach cancer among the 47 prefectures in Japan, and Aomori prefecture is one of the most severely impacted. The aims of this study were to determine the incidence and mortality rates of stomach cancer in Aomori prefecture in comparison with Japan as a whole and cast light on reasons underlying variation. Methods: Data on stomach cancer cases were extracted from the Aomori Cancer Registry Database. Incidence rates for specific stages at the time of diagnosis were cited from Monitoring of Cancer Incidence in Japan, and mortality rates for stomach cancer in Aomori prefecture and the whole of Japan were obtained from Vital Statistics. Age-standardised incidence and mortality rates were calculated using the direct method. Results: The age-standardised incidence rate of stomach cancer in Aomori prefecture was higher than in the whole of Japan for males but lower for females. However, the age-standardised mortality rates were higher in Aomori prefecture in both sexes. The proportion of localised cancers was lower in Aomori prefecture than in the whole of Japan for most age groups. Conclusions: The lower rate for localised cancer suggests that higher age-standardised mortality rates are due to delays in diagnosis, despite an attendance rate for stomach cancer screening was higher in Aomori prefecture than in the whole of Japan. One plausible explanation for the failure of successful early detection might be poor quality control during screening implementation that impedes early detection.
Stomach cancer;delays in diagnosis;age-standardised mortality rate
- Abnet CC, Corley DA, Freedman ND, Kamangar F (2015). Diet and upper gastrointestinal malignancies. Gastroenterology, 148, 1234 - 43. https://doi.org/10.1053/j.gastro.2015.02.007
- Brawley O, Goldberg P (2012). How We Do Harm: A Doctor Breaks Ranks About Being Sick in America. St. Martin's Press, New York.
- Cancer Registry and Statistics (2016). Cancer information service, national cancer center of Japan. Attendance rate of cancer screening by 47 prefectures in Japan. Retrieved 4 July 2016, from http://ganjoho.jp/reg_stat/statistics/dl/index.html.
- Dassen AE, Dikken JL, Bosscha K, et al (2014). Gastric cancer: decreasing incidence but stable survival in the Netherlands. Acta Oncol, 53, 138- 42. https://doi.org/10.3109/0284186X.2013.789139
- Forman DBF, Brewster DH, Gombe Mbalawa C, et al (2014). Cancer Incidence in Five Continents, Vol. X. IARC Scientific Publication No. 164. International Agency for Research on Cancer: Lyon pp, 126-908.
- Graham DY (2015). Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits. Gastroenterology, 148, 719-31. https://doi.org/10.1053/j.gastro.2015.01.040
- Inaba S, Hirayama H, Nagata C, et al (1999). Evaluation of a screening program on reduction of gastric cancer mortality in Japan: preliminary results from a cohort study. Prev med, 29, 102-6. https://doi.org/10.1006/pmed.1999.0507
- Kamineni A, Williams MA, Schwartz SM, et al (1999). The incidence of gastric carcinoma in Asian migrants to the United States and their descendants. Cancer Causes Control, 10, 77-83. https://doi.org/10.1023/A:1008849014992
- Lambert R, Guilloux A, Oshima A, et al (2002). Incidence and mortality from stomach cancer in Japan, Slovenia and the USA. Int J Cancer, 97, 811-8. https://doi.org/10.1002/ijc.10150
- Locke FB, King H (1980). Cancer mortality risk among Japanese in the United States. J Natl Cancer Inst, 65, 1149-56.
- Mizoue T, Yoshimura T, Tokui N, et al (2003). Prospective study of screening for stomach cancer in Japan. Int J Cancer, 106, 103-7. https://doi.org/10.1002/ijc.11183
- Rabeneck L, Lansdorp-Vogelaar I (2015). Assessment of a cancer screening program. Best practice & research. Clin Gastroenterol, 29, 979-85.
- Japan Gastroenterological Endoscopy Society (2016). List of specialists certified by Japan Gastroenterological Endoscopy Society. Retrieved 4 July 2016, from http://www.jges.net/index.php/member_submenu/archives/115.
- Verdecchia A, Mariotto A, Gatta G, et al (2003). Comparison of stomach cancer incidence and survival in four continents. Eur J Cancer, 39, 1603-9. https://doi.org/10.1016/S0959-8049(03)00360-5
- Vital, Health and Social Statistics Division, Ministry of Health, Labour and Welfare (2014). Vital Statistics of Japan. Retrieved 4 July 2016, from http://www.e-stat.go.jp/SG1/estat/GL08020103.do?_toGL08020103_&listID=000001137965&disp=Other&requestSender=dsearch.
- Zheng L, Wu C, Xi P, et al (2014). The survival and the long-term trends of patients with gastric cancer in Shanghai, China. BMC cancer, 14, 300. https://doi.org/10.1186/1471-2407-14-300