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Association of Poly (ADP-Ribose) Polymerase 1 Variants with Oral Squamous Cell Carcinoma Susceptibility in a South Indian Population

  • Anil, Sukumaran (Department of Preventive Dental Sciences, College of Dentistry, Prince Sattam Bin Abdulaziz University) ;
  • Gopikrishnan, PB (Department of Conservative Dentistry and Endodontist, PSM College of Dental Sciences and Research) ;
  • Basheer, Ashik Bin (Department of Oral and Maxillofacial Pathology, PSM College of Dental Sciences and Research) ;
  • Vidyullatha, BG (Department of Oral and Maxillofacial Surgery and Diagnostic sciences, King Saud Bin Abdulaziz University for Health Sciences) ;
  • Alogaibi, Yahya A (Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University) ;
  • Chalisserry, Elna P (Department of Maxillofacial Surgery & Diagnostic Sciences, College of Dentistry, College of Dentistry, Jazan University) ;
  • Javed, Fawad (Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester) ;
  • Dalati, MHN (Consultant Orthodontist and Restorative Dentist, Springs Dental Care) ;
  • Vellappally, Sajith (Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University) ;
  • Hashem, Mohamed Ibrahim (Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University) ;
  • Divakar, Darshan Devang (Dental Biomaterials Research Chair, Dental Health Department, College of Applied Medical Sciences, King Saud University)
  • Published : 2016.08.01

Abstract

Background: Oral cancers account for approximately 2% of all cancers diagnosed each year; however, the vast majority (80%) of the affected individuals are smokers whose risk of developing a lesion is five to nine times greater than that of non-smokers. Tobacco smoke contains numerous carcinogens that cause DNA damage, including oxidative lesions that are removed effectively by the base-excision repair (BER) pathway, in which poly (ADP-ribose) polymerase 1 (PARP-1), plays key roles. Genetic variations in the genes encoding DNA repair enzymes may alter their functions. Several studies reported mixed effects on the association between PARP-1 variants and the risk of cancer development. Till now no reported studies have investigated the association between PARP-1 variants and oral squamous cell carcinoma (OSCC) risk in an Indian population. Materials and Methods: In the present case control study 100 OSCC patients and 100 matched controls were genotyped using PARP1 single nucleotide peptides (SNP's) rs1136410 and rs3219090 using TaqMan assays. Results: The results indicated significantly higher risk with PARP1 rs1136410 minor allele "C" (OR=1.909; p=0.02942; CI, 1.060-3.439). SNP rs1136410 also showed significantly increased risk in patients with smoking habit at C/C genotype and at minor allele C. Conclusions: The PAPR-1 Ala762Val polymorphism may play a role in progression of OSCC. Larger studies with a greater number of samples are needed to verify these findings.

Keywords

Oral squamous cell carcinoma;poly (ADP-Ribose) polymerase 1;risk factor

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