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Colorectal Cancer Mortality in Shiraz, Iran

  • Dianatinasab, Mostafa (Student Research Committee, Shiraz University of Medical Sciences) ;
  • Ghaem, Haleh (Research Center for Health Sciences, Department of Epidemiology, School of Health) ;
  • Rezaianzadeh, Abbas (Research Center for Health Sciences, Department of Epidemiology, School of Health) ;
  • Hosseini, Seysd Vahid (Colorectal Research Center, Shiraz University of Medical Sciences) ;
  • Khazraei, Hajar (Colorectal Research Center, Shiraz University of Medical Sciences)
  • Published : 2016.08.01

Abstract

Background: Mortality among Iranian patients with colorectal cancer has not been fully examined and the factors associated with their survival are still controversial. This study aimed to determine the mortality rate and its related factors among the patients with colorectal cancer in southwestern regions in Iran. Materials and Methods: This prospective cohort study was conducted on 220 patients with colorectal cancer referred to Fahighi Hospital, Shiraz, Iran from 2009 to 2014. Data were collected from the patients' medical records and were analyzed using Cox regression analysis. Results: Over a median follow-up of 29.3 months, 56 out of the 220 patients (25.5%) died, 32 (14.5%) aged below 40 years, and 45.5% were female. Based on the results of multiple Cox regression analysis, family history of gastrointestinal cancer, stage III, former smoking, type of lesion (fungative and polypoid), and opium use were associated with a greater risk of colorectal cancer mortality (all P<0.05). Conclusions: This cohort study found that the mortality rate of colorectal cancer in Iran is lower than that in European countries. In addition, behavioral and clinical factors were significantly associated with the survival rate. Addressing the related factors would help healthcare providers and physicians provide the best care and improve the survival rate.

Keywords

Mortality;survival rate;colorectal cancer;Cox regression;Iran

Acknowledgement

Supported by : Shiraz University of Medical Sciences

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