Asian Pacific Journal of Cancer Prevention
- Volume 17 Issue 8
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- Pages.4037-4041
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- 2016
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- 1513-7368(pISSN)
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- 1513-7368(eISSN)
DOI QR Code
Conventional versus Doxorubicin-Eluting Beads Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: a Tertiary Medical Centre Experience in Malaysia
- Rahman, F Abdul (Gastroenterology Unit, Department of Medicine, Universiti Sains Islam Malaysia) ;
- Naidu, J (Gastroenterology Unit, Department of Medicine, Universiti Sains Islam Malaysia) ;
- Ngiu, CS (Gastroenterology Unit, Department of Medicine, Universiti Sains Islam Malaysia) ;
- Yaakob, Y (Endovascular and Interventional Unit, Department of Radiology, Universiti Sains Islam Malaysia) ;
- Mohamed, Z (Endovascular and Interventional Unit, Department of Radiology, Universiti Sains Islam Malaysia) ;
- Othman, H (Hepatobiliary Unit, Department of Surgery, Universiti Sains Islam Malaysia) ;
- Jarmin, R (Hepatobiliary Unit, Department of Surgery, Universiti Sains Islam Malaysia) ;
- Elias, MH (Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Universiti Sains Islam Malaysia) ;
- Hamid, N Abdul (Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Universiti Sains Islam Malaysia) ;
- Mokhtar, N Mohd (Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Universiti Sains Islam Malaysia) ;
- Ali, RA Raja (Gastroenterology Unit, Department of Medicine, Universiti Sains Islam Malaysia)
- Published : 2016.08.01
Abstract
Background: Hepatocellular carcinoma (HCC) is a common cancer that is frequently diagnosed at an advanced stage. Transarterial chemoembolisation (TACE) is an effective palliative treatment for patients who are not eligible for curative treatment. The two main methods for performing TACE are conventional (c-TACE) or with drug eluting beads (DEB-TACE). We sought to compare survival rates and tumour response between patients undergoing c-TACE and DEB-TACE at our centre. Materials and Methods: A retrospective cohort study of patients undergoing either treatment was carried out from January 2009 to December 2014. Tumour response to the procedures was evaluated according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Kaplan-Meier analysis was used to assess and compare the overall survival in the two groups. Results: A total of 79 patients were analysed (34 had c-TACE, 45 had DEB-TACE) with a median follow-up of 11.8 months. A total of 20 patients in the c-TACE group (80%) and 12 patients in the DEB-TACE group (44%) died during the follow up period. The median survival durations in the c-TACE and DEB-TACE groups were
Keywords
Transarterial chemoembolization;conventional;doxorubucin-eluting beads;hepatocellular carcinoma
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