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The Association of Circumcision and Prostate Cancer: A Meta-Analysis

  • Li, Yu-dan (Key Laboratory of Diseases of Urological System Gansu Province, Gansu Nephro-Urological Clinical Center, The Department of Urology, The Second Hospital of Lanzhou University) ;
  • Teng, Yang (The People's Hospital of Rizhao Donggang Qu) ;
  • Dai, Yu (Key Laboratory of Diseases of Urological System Gansu Province, Gansu Nephro-Urological Clinical Center, The Department of Urology, The Second Hospital of Lanzhou University) ;
  • Ding, Hui (Key Laboratory of Diseases of Urological System Gansu Province, Gansu Nephro-Urological Clinical Center, The Department of Urology, The Second Hospital of Lanzhou University)
  • Published : 2016.08.01

Abstract

Background: To investigate the association circumcision with prostate cancer. Materials and Methods: We searched PubMed, EMBASE, the Cochrane Library, and Chinese biomedicine literature database up to August 2015. All case-control studies were identified in which investigated the association circumcision with prostate cancer. Three authors independently assessed study quality and extracted data. All data were analyzed using RevMan 5.3 and STATA version 11.0. Results: Six case-control studies met the inclusion criteria. The pooled meta-analysis showed that there was a lower incidence of circumcision in prostate cancer patients compared with control (OR=0.90, 95% confidence interval [CI] 0.82-0.98, P=0.01). The results of meta-analysis also showed that no significant difference was found between circumcision and less aggressive prostate cancer (OR=0.93, 95% CI 0.83-1.04, P=0.19); however, there was a lower incidence of circumcision in more aggressive prostate cancer compared with control (OR =0.84, 95% CI 0.72-0.97, P=0.02). The Egger's results did not show any evidence of publication bias(P=0.798). Conclusions: In summary, within the limits of available data, male with circumcision appears to have a lower incidence of prostate cancer. In the future, high-quality multicenter studies are needed to thoroughly verify the outcome.

Keywords

Circumcision;prostate cancer;meta-analysis

Acknowledgement

Supported by : Central Universities, Gansu Nephro-Urological Clinical Center

References

  1. Backes DM, Kurman RJ, Pimenta JM, Smith JS (2009). Systematic review of human papillomavirus prevalence in invasive penile cancer. Cancer Causes Control, 20, 449-57. https://doi.org/10.1007/s10552-008-9276-9
  2. Bosch FX, Albero G, Castellsague X (2009). Male circumcision, human papillomavirus and cervical cancer: from evidence to intervention. J Fam Plann Reprod Health Care, 35, 5-7. https://doi.org/10.1783/147118909787072270
  3. Chaux A, Cubilla AL (2012). Advances in the pathology of penile carcinomas. Hum Pathol, 43, 771-89. https://doi.org/10.1016/j.humpath.2012.01.014
  4. De Marzo AM, Platz EA, Sutcliffe S, et al. (2007). Inflammation in prostate carcinogenesis. Nat Rev Cancer, 7, 256-69. https://doi.org/10.1038/nrc2090
  5. Dennis LK, Coughlin JA, McKinnon BC, et al (2009). Sexually transmitted infections and prostate cancer among men in the U.S. military. Cancer Epidemiol Biomarkers Prev, 18, 2665-71. https://doi.org/10.1158/1055-9965.EPI-08-1167
  6. Ewings P, Bowie C (1996). A case-control study of cancer of the prostate in Somerset and east Devon. Br J Cancer, 74, 661-6. https://doi.org/10.1038/bjc.1996.418
  7. GA Wells, B Shea, D O'Connell, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Available at:http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed: August 21, 2015.
  8. Goktas S, Yilmaz MI, Caglar K, et al (2005). Prostate cancer and adiponectin. Urol, 65, 1168-72. https://doi.org/10.1016/j.urology.2004.12.053
  9. Hayes RB, Pottern LM, Strickler H, et al. (2000). Sexual behaviour, STDs and risks for prostate cancer. Br J Cancer, 82, 718-25. https://doi.org/10.1054/bjoc.1999.0986
  10. Huang JQ, Sridhar S, Chen Y, Hunt RH (1998). Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterol, 114, 1169-79. https://doi.org/10.1016/S0016-5085(98)70422-6
  11. Jiang J, Li J, Yunxia Z, Zhu H, Liu J, Pumill C (2013). The role of prostatitis in prostate cancer: meta-analysis. PLoS One, 8, 85179. https://doi.org/10.1371/journal.pone.0085179
  12. Kheirandish P, Chinegwundoh F (2011). Ethnic differences in prostate cancer. Br J Cancer, 105, 481-5. https://doi.org/10.1038/bjc.2011.273
  13. Larke NL, Thomas SL, dos Santos Silva I, Weiss HA (2011). Male circumcision and penile cancer: a systematic review and meta-analysis. Cancer Causes Control, 22, 1097-110. https://doi.org/10.1007/s10552-011-9785-9
  14. Lightfoot N, Conlon M, Kreiger N, et al (2004). Medical history, sexual, and maturational factors and prostate cancer risk. Ann Epidemiol, 14, 655-62. https://doi.org/10.1016/j.annepidem.2003.11.006
  15. Mandel JS, Schuman LM (1987). Sexual factors and prostatic cancer: results from a case-control study. J Gerontol, 42, 259-64. https://doi.org/10.1093/geronj/42.3.259
  16. Morris BJ, Mindel A, Tobian AA, et al. (2012). Should male circumcision be advocated for genital cancer prevention? Asian Pac J Cancer Prev, 13, 4839-42. https://doi.org/10.7314/APJCP.2012.13.9.4839
  17. Morris BJ, Waskett J, Bailis SA (2007). Case number and the financial impact of circumcision in reducing prostate cancer. BJU Int, 100, 5-6.
  18. Mostafa MH, Sheweita SA, O’Connor PJ (1999). Relationship between schistosomiasis and bladder cancer. Clin Microbiol Rev, 12, 97-111.
  19. Newell GR, Fueger JJ, Spitz MR, Babaian RJ (1989). A casecontrol study of prostate cancer. Am J Epidemiol, 130, 395-8. https://doi.org/10.1093/oxfordjournals.aje.a115346
  20. Rosenblatt KA, Wicklund KG, Stanford JL (2001). Sexual factors and the risk of prostate cancer. Am J Epidemiol, 153, 1152-8. https://doi.org/10.1093/aje/153.12.1152
  21. Ross RK, Shimizu H, Paganini-Hill A, Honda G, Henderson BE (1987). Case-control studies of prostate cancer in blacks and whites in southern California. J Natl Cancer Inst, 78, 869-74.
  22. Siegfried N, Muller M, Deeks JJ, Volmink J (2009). Male circumcision for prevention of heterosexual acquisition of HIV in men. Cochrane Database Syst Rev, 15, CD003362..
  23. Spence AR, Rousseau MC, Karakiewicz PI, Parent ME (2014). Circumcision and prostate cancer: a population-based casecontrol study in Montreal, Canada. BJU Int, 114, 90-8. https://doi.org/10.1111/bju.12356
  24. Taylor ML, Mainous AG, 3rd, Wells BJ (2005). Prostate cancer and sexually transmitted diseases: a meta-analysis. Fam Med, 37, 506-12.
  25. Tobian AA, Serwadda D, Quinn TC, et al. (2009). Male circumcision for the prevention of HSV-2 and HPV infections and syphilis. N Engl J Med, 360, 1298-309. https://doi.org/10.1056/NEJMoa0802556
  26. Torre LA, Bray F, Siegel RL, et al (2015). Global cancer statistics, 2012. CA Cancer J Clin, 65, 87-108. https://doi.org/10.3322/caac.21262
  27. Walboomers JM, Jacobs MV, Manos MM, et al. (1999). Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol, 189, 12-9. https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
  28. Weiss HA, Thomas SL, Munabi SK, Hayes RJ (2006). Male circumcision and risk of syphilis, chancroid, and genital herpes: a systematic review and meta-analysis. Sex Transm Infect, 82, 101-9. https://doi.org/10.1136/sti.2005.017442
  29. Wright JL, Lin DW, Stanford JL (2012). Circumcision and the risk of prostate cancer. Cancer, 118, 4437-43. https://doi.org/10.1002/cncr.26653
  30. Xu F, Markowitz LE, Sternberg MR, Aral SO (2007). Prevalence of circumcision and herpes simplex virus type 2 infection in men in the United States: the National Health and Nutrition Examination Survey (NHANES), 1999-2004. Sex Transm Dis, 34, 479-84.