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Moringa oleifera Lam: Targeting Chemoprevention

  • Karim, Nurul Ashikin Abd (Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience) ;
  • Ibrahim, Muhammad Din (Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience) ;
  • Kntayya, Saie Brindha (Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience) ;
  • Rukayadi, Yaya (Faculty of Food Science and Technology, Universiti Putra Malaysia, UPM Serdang) ;
  • Hamid, Hazrulizawati Abd (Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang) ;
  • Razis, Ahmad Faizal Abdull (Laboratory of UPM-MAKNA Cancer Research, Institute of Bioscience)
  • Published : 2016.08.01

Abstract

Moringa oleifera Lam, family Moringaceae, is a perennial plant which is called various names, but is locally known in Malaysia as ''murungai'' or ''kelor''. Glucomoringin, a glucosinolate with from M. oleifera is a major secondary metabolite compound. The seeds and leaves of the plant are reported to have the highest amount of glucosinolates. M. oleifera is well known for its many uses health and benefits. It is claimed to have nutritional, medicinal and chemopreventive potentials. Chemopreventive effects of M. oleifera are expected due to the existence of glucosinolate which it is reported to have the ability to induce apoptosis in anticancer studies. Furthermore, chemopreventive value of M. oleifera has been demonstrated in studies utilizing its leaf extract to inhibit the growth of human cancer cell lines. This review highlights the advantages of M. oleifera targeting chemoprevention where glucosinolates could help to slow the process of carcinogenesis through several molecular targets. It is also includes inhibition of carcinogen activation and induction of carcinogen detoxification, anti-inflammatory, anti-tumor cell proliferation, induction of apoptosis and inhibition of tumor angiogenesis. Finally, for synergistic effects of M. oleifera with other drugs and safety, essential for chemoprevention, it is important that it safe to be consumed by human body and works well. Although there is promising evidence about M. oleifera in chemoprevention, extensive research need to be done due to the expected rise of cancer in coming years and to gain more information about the mechanisms involved in M. oleifera influence, which could be a good source to inhibit several major mechanisms involved in cancer development.

Keywords

Moringa oleifera;glucosinolate;glucomoringin;chemopreventive

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