Immunohistochemical Expression of B Cell Lymphoma-2 with Clinicopathological Correlation in Triple Negative Breast Cancers in Northern Pakistan

  • Zubair, Muhammad (Registrar Histopathology, Armed Forces institute of Pathology) ;
  • Hashmi, Shoaib Naiyar (Registrar Histopathology, Armed Forces institute of Pathology) ;
  • Afzal, Saeed (Registrar Histopathology, Armed Forces institute of Pathology) ;
  • Muhammad, Iqbal (Registrar Histopathology, Armed Forces institute of Pathology) ;
  • Din, Hafeez Ud (Registrar Histopathology, Armed Forces institute of Pathology) ;
  • Ahmed, Rabia (Registrar Histopathology, Armed Forces institute of Pathology)
  • Published : 2016.07.01


Background: Triple negative breast cancers (TNBCs) are high grade aggressive tumors generally with a poor prognosis, not responding to hormonal and anti Her2 Neu therapy. Expression of the antiapoptotic B cell lymphoma 2 gene (Bcl-2) is associated with low grade, slowly proliferating hormone receptor positive tumors with improved survival. Anti Bcl2 agents can be used as alternative targeted therapy in triple negative cancers. Materials and Methods: The objective of this study was to determine the immunohistochemical expression of Bcl2 in triple negative breast cancers and any correlation with clinicopathological variables in Northern Pakistan. Results: All 52 patients were females, aged between 28 and 80 years(average $48.0{\pm}12.1$). 28 cases (53.8%) were positive for Bcl2, this being associated with low grade invasive ductal carcinomas, lymph node metastasis and lymphovascular invasion. Conclusions: Bcl-2 may be an important prognostic factor and its expression might be used for targeted therapy using Anti Bcl2 drugs.


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