- Volume 17 Issue 7
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Immunohistochemical Expression of B Cell Lymphoma-2 with Clinicopathological Correlation in Triple Negative Breast Cancers in Northern Pakistan
- Zubair, Muhammad (Registrar Histopathology, Armed Forces institute of Pathology) ;
- Hashmi, Shoaib Naiyar (Registrar Histopathology, Armed Forces institute of Pathology) ;
- Afzal, Saeed (Registrar Histopathology, Armed Forces institute of Pathology) ;
- Muhammad, Iqbal (Registrar Histopathology, Armed Forces institute of Pathology) ;
- Din, Hafeez Ud (Registrar Histopathology, Armed Forces institute of Pathology) ;
- Ahmed, Rabia (Registrar Histopathology, Armed Forces institute of Pathology)
- Published : 2016.07.01
Background: Triple negative breast cancers (TNBCs) are high grade aggressive tumors generally with a poor prognosis, not responding to hormonal and anti Her2 Neu therapy. Expression of the antiapoptotic B cell lymphoma 2 gene (Bcl-2) is associated with low grade, slowly proliferating hormone receptor positive tumors with improved survival. Anti Bcl2 agents can be used as alternative targeted therapy in triple negative cancers. Materials and Methods: The objective of this study was to determine the immunohistochemical expression of Bcl2 in triple negative breast cancers and any correlation with clinicopathological variables in Northern Pakistan. Results: All 52 patients were females, aged between 28 and 80 years(average
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