- Volume 17 Issue 7
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Randomized Double-Blind Placebo-Controlled Trial of Propolis for Oral Mucositis in Patients Receiving Chemotherapy for Head and Neck Cancer
- Akhavan-Karbassi, Mohammad Hasan (Department of Oral and Maxillofacial Diseases Diagnosis, Shahid Sadoughi University of Medical Sciences) ;
- Yazdi, Mohammad Forat (Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences) ;
- Ahadian, Hakimeh (Department of Oral and Maxillofacial Diseases Diagnosis, Shahid Sadoughi University of Medical Sciences) ;
- Sadr-Abad, Maryam Jalili (Department of Oral and Maxillofacial Diseases Diagnosis, Shahid Sadoughi University of Medical Sciences)
- Published : 2016.07.01
Background: Propolis based preparations have a wide range of applications in various specialties of dentistry. The aim of this clinical trial was to test the efficacy of propolis as a mouthwash in the reduction of chemotherapy induced oral mucositis (OM) in a single center. Materials and Methods: In this randomised, controlled study patients undergoing chemotherapy were included consecutively and randomised to an experimental group receiving propolis mouthwash (n = 20) and a control group receiving diluted water (n=20). Oral mucositis, erythema and eating and drink ability were assessed at baseline and after 3 and 7 days using the World Health Organization (WHO) scale and the oral mucositis assessment scale (OMAS). Results: There were significant differences in OM, wound and erythema in propolis group compared to placebo, but no significant difference in eating and drink ability. However, it was interesting that 65% of the patients in the propolis group were completely healed at day 7 of the trial. No significant adverse events were reported by the patients. Conclusions: This study found that oral care with propolis as mouthwash for patients undergoing chemotherapy is an effective intervention to improve oral health. Our findings shouldlencourage health practitioners to apply propolis mouth rinse for the oral care of patients under chemotherapy.
- Choi SE, Kim HS (2012). Sodium bicarbonate solution versus chlorhexidine mouthwash in oral care of acute leukemia patients undergoing induction chemotherapy: a randomized controlled Trial. Asian Nurs Res (Korean Soc Nurs Sci), 6, 60-6.
- Castaldo S, Capasso F (2002). Propolis, an old remedy used in modern medicine. Fitoterapia, 73, S1-6. https://doi.org/10.1016/S0367-326X(01)00364-1
- Dodwad V, Kukreja BJ (2011). Propolis mouthwash: A new beginning. J Indian Soc Periodontol, 15, 121-5. https://doi.org/10.4103/0972-124X.84379
- Hegde KS, Bhat SS, Rao A, et al (2013). Effect of propolis on streptococcus mutans counts: An in vivo Study. Int J Clin Pediatr Dent, 6, 22-5. https://doi.org/10.5005/jp-journals-10005-1180
- Hwu YJ, Lin FY (2014). Effectiveness of propolis on oral health: a meta-analysis. J Nurs Res, 22, 221-9. https://doi.org/10.1097/jnr.0000000000000054
- Jacob A, Parolia A, Pau A, et al (2015). The effects of malaysian propolis and brazilian red propolis on connective tissue fibroblasts in the wound healing process. BMC Complement Altern Med, 25, 15,294. https://doi.org/10.1186/s12906-015-0814-1
- Jafarzadeh Kashi TS, Kasra Kermanshahi R, Erfan M, et al (2011) Evaluating the in-vitro antibacterial effect of Iranian propolis on oral microorganisms Iran. J Pharm Res, 10, 363-8.
- Javadzadeh Bolouri A, Pakfetrat A, Tonkaboni A, et al (2015). Preventing and therapeutic effect of propolis in radiotherapy induced mucositis of head and neck cancers: a triple-blind, randomized, placebo-controlled trial. Iran J Cancer Prev, 8, 4019.
- Mirzoeva OK, Calder PC (1996). The effect of propolis and its components on eicosanoid production during the inflammatory response. Prostaglandins Leukot Essent Fatty Acids, 55, 441-9. https://doi.org/10.1016/S0952-3278(96)90129-5
- Naidu MU, Ramana GV, Rani PU, et al (2004). Chemotherapyinduced and/or radiation therapy-induced oral mucositis--complicating the treatment of cancer. Neoplasia, 6, 423-31. https://doi.org/10.1593/neo.04169
- Palombo EA (2011). Traditional medicinal plant extracts and natural products with activity against oral bacteria: potential application in the prevention and treatment of oral diseases. Evid Based Complement Alternat Med, 680354.
- Sarvizadeh M, Hemati S, Meidani M, et al (2015) Morphine mouthwash for the management of oral mucositis in patients with head and neck cancer, Adv Biomed Res, 11, 4-44.
- Steinberg D, Kaine G, Gedalia I (1996). Antibacterial effect of propolis and honey on oral bacteria. Am J Dent, 9, 236-9.
- S VK (2014). Propolis in dentistry and oral cancer management. N Am J Med Sci, 6, 250-9.
- Redding SW (2005). Cancer therapy-related oral mucositis. J Dent Educ, 69, 919-29.
- Wong HM (2014). Oral Complications and management strategies for patients undergoing cancer therapy. Scientific World J, 2014, 581795.