- Volume 17 Issue 7
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Type 2 Diabetes Mellitus as a Risk Factor for Female Breast Cancer in the Population of Northern Pakistan
- Tabassum, Ifrah (Institute of Radiotherapy and Nuclear Medicine (IRNUM)) ;
- Mahmood, Humera (Department of Oncology, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI)) ;
- Faheem, Mohammad (Department of Oncology, Nuclear Medicine, Oncology and Radiotherapy Institute (NORI))
- Published : 2016.07.01
Background: There has been much research work in the past to ascertain the association between type 2 diabetes mellitus and breast cancer, but definitive evidence has been scanty. The present study was carried out to determine the association of type 2 diabetes mellitus with breast cancer in the female population of Northern Pakistan. Materials and Methods: This case-control study was carried out in the Oncology Department of NORI Hospital. A total of 400 patients were included. Data were entered into PSPP 0.8.1. Two-tailed significance tests were used and a p-value of 0.05 was considered significant. Results: There were a higher percentage of postmenopausal women in the diabetic breast cancer patients' group as compared to the non-diabetic subset. The odds ratio for the association between diabetes and risk of developing breast cancer was elevated with statistical significance (OR = 2.96; 95 % CI =1.3-6.3; p-value=0.004). The results of our study showed that diabetes is associated with a risk of developing breast cancer, especially in postmenopausal women (OR = 4.928; 95 % CI = 2.1-11.3; p-value=0.001). The association was particularly marked in obese subjects (OR = 31.49; 95 % CI = 1.8-536; p- value=0.01), as compared to non-obese subjects (OR = 0.642; 95 % CI = 0.2-1.7). Conclusions: Diabetes is strongly associated with obesity and it tends to increase the risk of breast Cancer, especially in postmenopausal women. A high-risk subset for breast cancer comprised postmenopausal, diabetic and overweight women.
- Carmichael A (2006). Review article: obesity as a risk factor for development and poor prognosis of breast cancer. Br J Obstetrics Gynaecol, 113, 1160-6. https://doi.org/10.1111/j.1471-0528.2006.01021.x
- Chaudhuri P, Chaudhuri B, Patel N (1986). Modulation of estrogen receptor by insulin and its biologic significance. Archives Surg, 121, 1322-5. https://doi.org/10.1001/archsurg.1986.01400110114019
- Cleveland R, North K, Stevens J, et al (2012). The association of diabetes with breast cancer incidence and mortality in the long island breast cancer study project. Cancer Causes Control, 23, 1193-203. https://doi.org/10.1007/s10552-012-9989-7
- Faheem M, Khurram M, Jafri I, et al (2007). Risk factors for breast cancer in patients treated at NORI Hospital, Islamabad. J Pakistan Medical Associat, 57, 242.
- Guastamacchia E, Resta F, Mangia A, et al (2003). Breast cancer: biological characteristics in postmenopausal type 2 diabetic women. Identification of therapeutic targets. Current Drug Targets-Immune, Endocrine and Metabolic Disorders, 3, 205-9. https://doi.org/10.2174/1568008033340199
- Hamelers I, Steenbergh P (2003). Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells. Endocrine-related Cancer, 10, 331-45. https://doi.org/10.1677/erc.0.0100331
- Larsson S, Mantzoros C, Wolk A (2007). Diabetes mellitus and risk of breast cancer: a meta-analysis. Int J Cancer, 121, 856-62. https://doi.org/10.1002/ijc.22717
- Macaulay V (1992). Insulin-like growth factors and cancer. Br J Cancer, 65, 311. https://doi.org/10.1038/bjc.1992.65
- McTernan P, Anderson L, Anwar A, et al (2002). Glucocorticoid regulation of p450 aromatase activity in human adipose tissue: gender and site differences. J Clin Endocrinol Metabolism, 87, 1327-36. https://doi.org/10.1210/jcem.87.3.8288
- Michels K, Solomon C, Hu F, et al (2003). Type 2 diabetes and subsequent incidence of breast cancer in the Nurses' Health Study. Diabetes Care, 26, 1752-8. https://doi.org/10.2337/diacare.26.6.1752
- Novosyadlyy R, Lann D, Vijayakumar A, et al (2010). Insulinmediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res, 70, 741-51. https://doi.org/10.1158/0008-5472.CAN-09-2141
- Sachdev D, Yee D (2001). The IGF system and breast cancer. Endocrine-Related Cancer, 8, 197-209. https://doi.org/10.1677/erc.0.0080197
- World Health Organization (2003). The world health report 2003: shaping the future. World Health Organization.
- World Health Organization (2008). Pacific physical activity guidelines for adults: Framework for accelerating the communication of physical activity guidelines. Manila. WHO Regional Office for the Western Pacific.