- Volume 17 Issue 7
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Bone Mineral Density and Breast Cancer Risk Factors among Premenopausal and Postmenopausal Women - A Systematic Review
- Zain, Norhayati Mohd (Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz) ;
- Seriramulu, Vengkatha Priya (Department of Medical Imaging, Faculty of Health Sciences, KPJ Healthcare University College) ;
- Chelliah, Kanaga Kumari (Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz)
- Published : 2016.07.01
Background: Bone mineral density (BMD) is a lifetime marker of estrogen in a woman's body and has been associated with increased breast cancer risk. Nonetheless the actual association is still debatable. Furthermore, estrogen is very crucial in maintaining human bone density and gradually decreases over age. A systematic search was conducted to assess any association of BMD with breast cancer risk factors among premenopausal and postmenopausal women. Materials and Methods: Review identification was performed through databases searching on MEDLINE, CINAHL and SCOPUS and 19 qualified studies were elected. The keywords used were "bone mineral density", "breast cancer", and "breast density". Results: A total of 19 articles showed variation with the majority of the studies focused on postmenopausal and a few focused on premenopausal women. Overall there was no concensus on effects. Conclusions: An enormous effort is being undertaken by researchers to prove that BMD might be one of the significant risk factors for breast cancer.
Bone mineral density;breast density;breast cancer;premenopausal women;postmenopausal women
Supported by : University Kebangsaan Malaysia
- American Cancer Society. Cancer Facts and Figures (2016). Atlanta, GA: American Cancer Society, 2016 retrieved on 13th March 2016 from http://ww5.komen.org/BreastCancer/FactsandStatistics.html
- Buist DS, Anderson ML, Taplin SH, LaCroix AZ (2004). The relationship between breast density and bone mineral density in postmenopausal women. Cancer, 101, 1968-76. https://doi.org/10.1002/cncr.20565
- Cauley JA, Song J, Dowsett SA, et al (2007). Risk factors for breast cancer in older women: The relative contribution of bone mineral density and other established risk factors. Breast Cancer Res Treat, 102, 181-8. https://doi.org/10.1007/s10549-006-9326-5
- Chen Z, Arendell L, Aickin M, et al (2008). Hip bone density predicts breast cancer risk independently of gail score: Results from the women's health initiative. Cancer, 113, 907-15. https://doi.org/10.1002/cncr.23674
- Conde D.M, Costa-Paiva L, Martinez EZ, et al (2014). Cardiovascular risk in postmenopausal women with and without breast cancer. European J Obstetrics Gynecol Reproductive Biol, 183, 10-1. https://doi.org/10.1016/j.ejogrb.2014.10.004
- Crandall C, Palla S, Reboussin B, et al (2005). Positive association between mammographic breast density and bone mineral density in the Postmenopausal Estrogen/Progestin Interventions Study. Breast Cancer Res, 7, 922-8. https://doi.org/10.1186/bcr1327
- Crandall C.J, Zheng Y, Karlamangla A, et al (2007). The association between mammographic breast density and bone Mineral Density in the Study of Women's Health across the Nation. Ann Epidemiol, 17, 575-83. https://doi.org/10.1016/j.annepidem.2007.03.012
- Fraenkel M, Novack, V, Liel Y, et al (2013). Association between bone mineral density and incidence of breast cancer. PLoS ONE, 8, 70980. https://doi.org/10.1371/journal.pone.0070980
- Friedenreich CM (2011) Physical activity and breast cancer: review of the epidemiologic evidence and biologic mechanisms. Recent Results Cancer Res, 188, 125-39
- Gail MH, Brinton LA, Byar DP, et al (1989) Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst, 81, 1879-86 https://doi.org/10.1093/jnci/81.24.1879
- Grenier D, Cooke A.L, Lix L, et al (2011). Bone mineral density and risk of postmenopausal breast cancer. Breast Cancer Res Treat, 126, 679-86. https://doi.org/10.1007/s10549-010-1138-y
- Gupta R, Alhajri FA, Mohammed AM, et al (2008). Relationship between mammography breast density and bone mineral density. J Clin Densitom, 11, 431-6. https://doi.org/10.1016/j.jocd.2007.11.001
- Hong J, Holcomb VB, Dang F, et al (2010). Alcohol consumption, obesity, estrogen treatment and breast cancer. Anticancer Res, 30, 1-8.
- Jemal A, Siegel R, Ward, E, et al (2009). Cancer Statistics, 2009 both sexes female both sexes estimated deaths. CA Cancer J Clin, 1-25.
- Kalder M, Jager C, Seker-Pektas B, et al (2011). Breast cancer and bone mineral density: the Marburg Breast Cancer and Osteoporosis Trial (MABOT II). Climacteric, 14, 352-61. https://doi.org/10.3109/13697137.2011.557754
- Kerlikowske K, Shepherd J, Creasman J, et al (2005). Are breast density and bone mineral density independent risk factors for breast cancer? J National Cancer Ins, 105, 368-74.
- Key TJ, Appleby PN, Reeves GK, et al (2011) For the endogenous hormones and breast cancer collaborative group. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer, 709-22,
- Komulainen M.H, Kroger H, Tuppurainen M.T, et al (1998). HRT and Vit D in prevention of non-vertebral fractures in postmenopausal women; A 5 year randomized trial. Maturitas. 45-54.
- Kritz-Silverstein D, Schneider DL, Sandwell J (2006). Breast cancer and bone mass in older women: Is bone density prescreening for mammography useful? Osteoporosis Int, 17, 1196-201. https://doi.org/10.1007/s00198-006-0124-z
- Mann G.B, Kang Y.C, Brand C, et al (2009). Secondary causes of low bone mass in patients with breast cancer: A need for greater vigilance. J Clin Oncol, 27, 3605-10. https://doi.org/10.1200/JCO.2008.20.2549
- McTiernan A. (2008). Mechanisms linking physical activity with cancer. Nat Rev Cancer, 8, 205-11 https://doi.org/10.1038/nrc2325
- Melton L, Hartmann L et al (2012). Fracture risk in women with breast cancer: a population- based study. Mineral Res, 27, 1196-205. https://doi.org/10.1002/jbmr.1556
- National Breast Cancer Foundation, Inc, (2015). retrieved on 13th March 2016 from http://www.nationalbreastcancer.org/breast-cancer-risk-factors
- Nelson HD, Zakher B, Cantor A, et al (2012). Risk factors for breast cancer for women aged 40 to 49 years: a systematic review and meta-analysis. Ann Intern Med, 156, 635-48 https://doi.org/10.7326/0003-4819-156-9-201205010-00006
- Qu X, Zhang X, Qin A, et al (2013). Bone mineral density and risk of breast cancer in postmenopausal women. Breast Cancer Res Treat, 138, 261-71. https://doi.org/10.1007/s10549-013-2431-3
- Reeves G.K, Pirie K., Beral V, et al (2007). Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study. BMJ (Clinical Research Ed.), 335, 1134. https://doi.org/10.1136/bmj.39367.495995.AE
- Schutze M, Boeing H, Pischon T, et al (2011). Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ (Clinical Research Ed.), 342, 1584. https://doi.org/10.1136/bmj.d1584
- Stewart A, Kumar V, Torgerson DJ, et al (2005). Axial BMD, change in BMD and bone turnover do not predict breast cancer incidence in early postmenopausal women. Osteoporosis Int, 16, 1627-32. https://doi.org/10.1007/s00198-005-1886-4
- Sung J, Song YM., Stone J, et al (2011). The relationship between bone mineral density and mammographic density in Korean women: the Healthy Twin study. Breast Cancer Res Treat, 129, 583-91. https://doi.org/10.1007/s10549-011-1523-1
- Tremollieres F, Ribot C (2010). Bone mineral density and prediction of non-osteoporotic disease. Maturitas, 65, 348-51. https://doi.org/10.1016/j.maturitas.2009.12.023
- Tremollieres FA1, Pouilles JM, Laparra J, Ribot C (2008). Bone mineral density at menopause does not predict breast cancer incidence. Osteoporos Int, 9, 1497-504.
- Van der Klift M, de Laet EDH, Coebergh JWW et al (2003). Bone mineral density and the risk of cancer: the Rotterdam study. Bone, 32, 211-6 https://doi.org/10.1016/S8756-3282(02)00972-9
- Weiss LK, Burkman RT, Cushing-Haugen KL, et al (2002). Hormone replacement therapy regimens and breast cancer risk (1). Obstet Gynecol, 100, 1148-58.
- Wu Y, Zhang D, Kang S (2013). Physical activity and risk of breast cancer: A meta-analysis of prospective studies. Breast Cancer Res Treat, 137, 869-82. https://doi.org/10.1007/s10549-012-2396-7
- Yong M, Atkinson C, Newton KM, et al (2009). Associations between endogenous sex hormone levels and mammographic and bone densities in premenopausal women. Cancer Causes Control, 137, 1039-53.
- Zambetti A, Tartter PI (2013). Bone mineral density is a prognostic factor for postmenopausal caucasian women with breast cancer. Breast J, 19, 168-72. https://doi.org/10.1111/tbj.12072