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Morin, a Flavonoid from Moraceae, Inhibits Cancer Cell Adhesion to Endothelial Cells and EMT by Down-regulating VCAM-1 and N-cadherin

  • Lee, Jeong-Hee (Department of Pathology, Institute of Health Sciences) ;
  • Jin, Hana (Department of Pharmacology, Institute of Health Sciences) ;
  • Lee, Won Sup (Department of Internal Medicine, Institute of Health Sciences) ;
  • Nagappan, Arulkumar (Department of Internal Medicine, Institute of Health Sciences) ;
  • Choi, Yung Hyun (Department of Biochemistry, Dongeui University College of Oriental Medicine and Department of Biomaterial Control (BK21 program), Dongeui University Graduate School) ;
  • Kim, GonSup (School of Veterinary Medicine, Gyeongsang National University School of Medicine) ;
  • Jung, Jin-Myung (Department of Neurosurgery, Institute of Health Sciences) ;
  • Ryu, Chung Ho (Division of Applied Life Science (BK 21 Program), Institute of Agriculture and Life Science, Gyeongsang National University) ;
  • Shin, Sung Chul (Department of Chemistry, and Research Institute of Life Science, Gyeongsang National University School of Medicine) ;
  • Hong, SoonChan (Department of Surgery, Institute of Health Sciences) ;
  • Kim, Hye Jung (Department of Pharmacology, Institute of Health Sciences)
  • Published : 2016.07.01

Abstract

Morin, a flavonoid found in figs and other Moraceae species, displays a variety of biological actions, exerting anti-oxidant, anti-inflammatory and anti-carcinogenic effects. Here, we investigated the anti-cancer activity of morin focusing on anti-adhesive influence. We performed experiments with MDA-MB-231 human breast cancer cells. Morin inhibited TNF-induced cancer cell adhesion to human umbilical vein endothelial cells (HUVECs) without showing any toxicity. It further inhibited the expression of VCAM-1 on MDA-MB-231 cells as well as HUVECs. Morin also decreased the expression of N-cadherin on MDA-MB-231 cells. In addition, there was apparent anti-metastatic activity in vivo. In conclusion, this study suggested that morin inhibits cancer cell adhesion to HUVECs by reducing VCAM-1, and EMT by targeting N-cadherin, and that it features anti-metastatic activity in vivo. Further investigation of possible anti-metastatic activity of morin against human breast cancer cells is warranted.

Keywords

Breast cancer cells;morin;metastasis;adhesion;VCAM-1;N-cadherinn;downregulation

Acknowledgement

Supported by : Ministry of Health & Welfar

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