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Pleiotropic Roles of Metalloproteinases in Hematological Malignancies: an Update

  • Chaudhary, Ajay K (Department of Immunohematology, National Institute of Immunohematology, KEM Hospital Campus) ;
  • Chaudhary, Shruti (Hematopathology Laboratory, Tata Memorial Hospital) ;
  • Ghosh, Kanjaksha (Department of Immunohematology, National Institute of Immunohematology, KEM Hospital Campus) ;
  • Nadkarni, A (Department of Immunohematology, National Institute of Immunohematology, KEM Hospital Campus)
  • Published : 2016.07.01

Abstract

Controlled remodeling of the extracellular matrix (ECM) is essential for cell growth, invasion and metastasis. Matrix metalloproteinases (MMPs) are a family of secreted, zinc-dependent endopeptidases capable of degradation of ECM components. The expression and activity of MMPs in a variety of human cancers have been intensively studied. They play important roles at different steps of malignant tumor formation and have central significance in embryogenesis, tissue remodeling, inflammation, angiogenesis and metastasis. However, increasing evidence demonstrates that MMPs are involved earlier in tumorigenesis. Recent studies also suggest that MMPs play complex roles in tumor progression. MMPs and membrane type (MT)-MMPs are potentially significant therapeutic targets in many cancers, so that designing of specific MMP inhibitors would be helpful for clinical trials. Here, we review the pleiotropic roles of the MMP system in hematological malignancies in-vitro and in-vivo models.

Keywords

Matrix metalloproteinases;tumorigenesis;MMP inhibitors;leukemias

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