Metastasis Risk Reduction Related with Beta-Blocker Treatment in Mexican Women with Breast Cancer

  • Parada-Huerta, E (Naval Medical School, Secretary of the Navy) ;
  • Alvarez-Dominguez, TP (Department of Pathology, High- Specialty Naval General Hospital (HOSGENAES)) ;
  • Uribe-Escamilla, R (Division of Neurosciences, National Institute of Rehabilitation (INR)) ;
  • Rodriguez-Joya, JF (Naval Clinic South (CLINISUR)) ;
  • Ponce-Medrano, JA Diaz (Naval Medical School) ;
  • Padron-Lucio, S (Branch, Naval Medical School, SEMAR) ;
  • Alfaro-Rodriguez, A (Division of Neurosciences, National Institute of Rehabilitation (INR)) ;
  • Bandala, C (Division of Neurosciences, National Institute of Rehabilitation (INR))
  • Published : 2016.06.01

Abstract

Background: Breast Cancer (BCa) is the most common malignant tumour in Mexican women. In BCa, several studies have linked ${\beta}2-adrenergic$ receptor activation with increased tumour growth and progression as related with Epinephrine-NorEpinephrine (E-NE) stimulation. The aim of this study was to describe Beta-Blocker (BB) treatment related with reduction of the risk of metastasis in Mexican patients with BCa. Materials and Methods: We collected data of 120 patients seen at the High-Specialty Naval General Hospital in Mexico City (HOSGENAES), all of these with a histopathological diagnosis of BCa. Four groups of patients were divided as follows: without Systemic Arterial Hypertension (SAH); with SAH treatment with non-selective BB; with SAH treatment with selective BB, and with SAH treatment with other antihypertensive drugs. Chi-square, Mantel-Haenszel, Student t, and ANOVA tests were performed for data analysis. Results: On average, patients were $54.8{\pm}11.8$ years of age. Risk factors such as smoking and consuming alcohol exhibited a frequency of 33 and 36.5% respectively. Clinical stages III- IV were found in 50% of patients, while, 30% of patients had arterial hypertension (n=29 and N=96, respectively) and 17.5% used BB. One hundred percent of patients with arterial hypertension treated with BB for ${\beta}1$ - and ${\beta}2$ -adrenergic-receptors did not present metastasis globally, but patients treated with ${\beta}1$ BB presented 30% of metastasis while patients treated with no BB or without SAH had around 70% of metastasis. Conclusions: In Mexican patients with BCa and SAH treated with non-selective (${\beta}1$- and ${\beta}2-adrenergic$ receptors) BB, a decrease in the risk for metastasis was observed at the time of diagnosis.

Keywords

Breast cancer;beta-blocker;arterial hypertension;metastasis

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