Curcumin: a Polyphenol with Molecular Targets for Cancer Control

  • Qadir, Muhammad Imran (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University) ;
  • Naqvi, Syeda Tahira Qousain (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University) ;
  • Muhammad, Syed Aun (Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University)
  • Published : 2016.06.01

Abstract

Curcumin, is a polyphenol from Curcuma longa (turmeric plant), is a polyphenol that belongs to the ginger family which has long been used in Ayurveda medicines to treat various diseases such as asthma, anorexia, coughing, hepatic diseases, diabetes, heart diseases, wound healing and Alzheimer's. Various studies have shown that curcumin has anti-infectious, anti-inflammatory, anti-oxidant, hepatoprotective, thrombosuppressive, cardio protective, anti-arthritic, chemo preventive and anti-carcinogenic activities. It may suppress both initiation and progression stages of cancer. Anticancer activity of curcumin is due to negative regulation of inflammatory cytokines, transcription factors, protein kinases, reactive oxygen species (ROS) and oncogenes. This review focuses on the different targets of curcumin to treat cancer.

Keywords

Curcumin;cancer;molecular targets of curcumin

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