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Prognostic Value of MAC30 Expression in Human Pure Squamous Cell Carcinomas of the Lung

  • Ding, Hui (Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University) ;
  • Gui, Xian-Hua (Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School) ;
  • Lin, Xu-Bo (Department of Integrative Biology and Pharmacology, Medical School, the University of Texas Health Science Center at Houston) ;
  • Chen, Ru-Hua (Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University) ;
  • Cai, Hou-Rong (Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School) ;
  • Fen, Yan (Department of Respiratory Medicine, Yixing People Hospital, Affiliated Jiangsu University) ;
  • Sheng, Yun-Lu (Department of Elder Endocrinology, the First Affiliated Hospital with Nanjing Medical University)
  • Published : 2016.05.01

Abstract

Recent evidence haas indicated that meningioma-associate protein (MAC30) exhibits different expression patterns in various tumors. However, little is known about the value of MAC30 in human squamous cell carcinoma of lung (SQCLC). The purpose of our study was to investigate the expression of MAC30 and to explore its clinical significance in SQCLC patients. A total of 156 Chinese patients diagnosed with SQCLC were selected for this study. The expression of MAC30 in all tissues was confirmed by immunohistochemical staining. Quantitative real-time PCR was performed to analyze MAC30 mRNA expression in 32 cases of SQCLC patients with corresponding non-tumor lung tissues. We observed enhanced mRNA expression of MAC30 in SQCLC as compared to control samples. Further, elevated MAC30 protein expression was strongly associated with poor tumor differentiation, TNM stage, and lymph node metastasis. In addition, we observed that patients with increased MAC30 expression demonstrated poor overall survival. Multivariate analysis explicated that increased MAC30 expression was a valuable independent predictable factor for poor tumor differentiation and short survival in SQCLC patients. Our present study suggests that MAC30 may serve as a biomarker for poor tumor differentiation and outcomes of patients with SQCLC.

Keywords

MAC30;squamous lung cancer;metastasis;prognosis

Acknowledgement

Supported by : National Natural Science Foundation of China

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