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Right-Sided and Left-Sided Colon Cancers are Two Distinct Disease Entities: an Analysis of 200 Cases in Pakistan

  • Hussain, Mudassar (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital) ;
  • Waqas, Omer (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital) ;
  • Hassan, Usman (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital) ;
  • Loya, Asif (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital) ;
  • Akhtar, Noreen (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital) ;
  • Mushtaq, Sajid (Department of Pathology, Shaukat Khanum Memorial Cancer Hospital) ;
  • Yusuf, Muhammad Aasim (Department of Internal Medicine, Shaukat Khanum Memorial Cancer Hospital) ;
  • Syed, Aamir Ali (Department of Surgery, Shaukat Khanum Memorial Cancer Hospital)
  • Published : 2016.05.01

Abstract

Background: There is growing evidence that there are differences in histological and genetic characteristics along with clinical behavior between right- and left-sided colon carcinomas. We have compared various parameters of the two types and assessed associations of the results with prognosis in patients in Pakistan. Materials and Methods: We reviewed 200 cases from our institutional database; 100 cases of right-sided and 100 cases of left-sided colon cancer. Parameters including age, gender, TNM stage, histological features and clinical outcome were analyzed. Results: The patients with right-sided colon cancer were significantly older as compared to their counterparts with left-sided cancer. They presented with a lumbar mass rather than symptoms of obstruction and perforation as seen in left-sided colon cancers, and the histology showed higher percentage of poorly differentiated tumors with advanced pT stage. Moreover, Crohn's-like reactions, intra tumoral lymphocyte responses and other poor prognostic factors like lymph vascular invasion and perineural invasion were more common in right-sided cancers. Conclusions: We found that right- and left-sided colon cancers are different from each other in terms of clinical presentation, histology and clinical behavior. Right-sided colon cancers are more aggressive and are associated with poorer clinical outcome as compared to left sided colon cancers in our population.

Keywords

Colon cancer;right-sided;left sided;prognosis;Pakistan

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