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Animal Model for Regeneration of Olfactory Sensory Neurons

후각신경세포의 손상 및 재생 연구모델의 융합연구

  • Jeong, Yun-Mi (Department of Biology, Chungnam National University) ;
  • Park, Jong-Su (Department of Biology, Chungnam National University) ;
  • Kim, Cheol-Hee (Department of Biology, Chungnam National University) ;
  • You, Kwan-Hee (Department of Biology, Chungnam National University)
  • Received : 2016.03.31
  • Accepted : 2016.04.12
  • Published : 2016.04.30

Abstract

The olfactory system is an important model for the study of neuronal degeneration and regeneration, including neuronal diseases. When the olfactory sensory neurons are damaged by nerve injury or are exposed to environmental factors, they degenerate and are replaced by regenerating neurons. To monitor neuronal degeneration in living animal, we established an olfactory-specific GFP transgenic zebrafish. The effects of Triton X-100 or sodium acetate on the olfactory system were examined. A significant decrease in the number of GFP-positive olfactory sensory neurons was observed after chemical lesion. We found a recovery of GFP-positive neurons by 2 days posttreatment. From these results, we expect that further studies of olfactory degeneration and regeneration using this transgenic zebrafish will provide important advances for the study of neuronal degeneration and regeneration.

Keywords

Olfactory dysfunction;Anosmia;Regeneration;Animal model;Convergence

Acknowledgement

Grant : BK21플러스

Supported by : 충남대학교

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