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Investigating the Frequency of the ERCC1 Gene C8092A Polymorphism in Iranian Patients with Advanced Gastric Cancer

  • Mokmeli, Sharareh (Biology Research Center, Zanjan Branch, Islamic Azad University) ;
  • Tehrani, Golnaz Asaadi (Department of Genetics, Zanjan Branch, Islamic Azad University) ;
  • Zamiri, Reza Eghdam (Radiation Oncology Department, Tabriz Medical University) ;
  • Bahrami, Tayyeb (Genetic Research Center, University of Social Welfare and Rehabilitation Sciences (USWR))
  • Published : 2016.04.11

Abstract

Background: Platinum compounds are the main drugs for treatment of advanced gastric cancer. Previous studies have shown that clinical outcome with platinum-based compounds depends on ERCC1 polymorphisms. The aim of this study was to investigate the frequency of a common polymorphism of ERCC1 gene (C8092A) in Iranian patients with advanced gastric cancer receiving platinum chemotherapy. Materials and Methods: Genetic analysis of the ERCC1 C8092A polymorphism was performed by the PCR - RFLP method using 50 paraffin-embedded tissue specimens. Results: Of the 50 cases, 32% of individuals showed CC genotype, 24% of them had CA genotype and 44% of patients had AA genotype. Conclusions: Based on the results, using of platinum-based chemotherapy would be expected to be specifically beneficial in only 32% of patients.

Acknowledgement

Supported by : Islamic Azad University of Zanjan

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