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Oridonin Suppresses Proliferation of Human Ovarian Cancer Cells via Blockage of mTOR Signaling

  • Xia, Rong (Department of Transfusion, Huashan Hospital, Fudan University) ;
  • Chen, Sun-Xiao (Changzheng Hospital, Second Military Medical University) ;
  • Qin, Qin (Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University) ;
  • Chen, Yan (Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University) ;
  • Zhang, Wei-Wei (Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University) ;
  • Zhu, Rong-Rong (Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University) ;
  • Deng, An-Mei (Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University)
  • Published : 2016.03.07

Abstract

Oridonin, an ent-kaurane diterpenoid compound isolated from the traditional Chinese herb Rabdosia rubescens, has shown various pharmacological and physiological effects such as anti-tumor, anti-bacterial, and anti-inflammatory properties. However, the effect of oridonin on human ovarian cancer cell lines has not been determined. In this study, we demonstrated that oridonin inhibited ovarian cancer cell proliferation, migration and invasion in a dose-dependent manner. Furthermore, we showed oridonin inhibited tumor growth of ovarian cancer cells (SKOV3) in vivo. We then assessed mechanisms and found that oridonin specifically abrogated the phosphorylation/activation of mTOR signaling. In summary, our results indicate that oridonin is a potential inhibitor of ovarian cancer by blocking the mTOR signaling pathway.

Keywords

Oridonin;ovarian cancer;mTOR signal pathway;suppress proliferation

Acknowledgement

Supported by : National Science Foundation of China

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  1. Oridonin induces apoptosis in human oral cancer cells via phosphorylation of histone H2AX vol.125, pp.6, 2017, https://doi.org/10.1111/eos.12387
  2. PIM Kinases and Their Relevance to the PI3K/AKT/mTOR Pathway in the Regulation of Ovarian Cancer vol.8, pp.1, 2018, https://doi.org/10.3390/biom8010007