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A 40-year Retrospective Clinicopathological Study of Ameloblastoma in Iran

  • Saghravanian, Nasrollah (Oral and Maxillofacial Diseases Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences) ;
  • Salehinejad, Jahanshah (Dental Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences) ;
  • Ghazi, Narges (Dental Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences) ;
  • Shirdel, Mohammad (Department of Prosthodontic, School of Dentistry, Vienna University of Medical Sciences) ;
  • Razi, Mahsa (Private Office)
  • Published : 2016.03.07

Abstract

Ameloblastoma is the most common epithelial odontogenic tumor. It may show locally invasive behavior resulting in recurrence and malignancy. Therefore, appropriate diagnosis of this tumor is necessary. The aim of this study was to evaluate clinicopathological characteristics of ameloblastomas in an Iranian population. We present a 40-year retrospective study of patients diagnosed from 1971 to 2010 in the Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mashhad, Iran. Information gathered from patient records included age, gender, tumor location and histologic type. The frequency of odontogenic tumors among all lesions was 2.08% and ameloblastoma with 88 samples demonstrated the greatest prevalence (41.5%). Regarding gender, 60% of samples occurred in males. The mean age of studied patients was $33.02{\pm} 15.74years$ with a peak of occurrence in the third decade of life. The most frequent location of tumor was the mandibles (93.2%). Eighty five (96.6%) tumors were recorded as benign and 3 (3.4%) as malignant. Of benign tumors, 62 (72.9%), 20 (23.5%) and 3 (3.6%) cases were of conventional, unicyctic and peripheral types, respectively. In contrast to most previous studies, the most common histologic subtype in the present study was plexiform. Knowledge of the incidence of ameloblastoma and its clinicopathologic features including most common location, gender and age distribution in different ethnogeographic backgrounds is necessary for accurate diagnosis and proper treatment.

Keywords

Odontogenic tumor;ameloblastoma;plexiform

Acknowledgement

Supported by : Mashhad University of Medical Sciences

References

  1. Adebayo E, Ajike S, Adekeye E (2005). A review of 318 odontogenic tumors in Kaduna, Nigeria. J Oral Maxillofac Surg, 63, 811-9. https://doi.org/10.1016/j.joms.2004.03.022
  2. Adebiyi KE, Ugboko VI, Omoniyi-Esan GO, (2006). Clinicopathological analysis of histological variants of ameloblastoma in a suburban Nigerian population. Head Face Med, 2, 42. https://doi.org/10.1186/1746-160X-2-42
  3. Adeline VL, Dimba EA, Wakoli KA, et al (2008). Clinicopathologic features of ameloblastoma in Kenya: a 10-year audit. J Craniofac Surg, 19, 1589-93. https://doi.org/10.1097/SCS.0b013e31818c0504
  4. Arotiba GT, Ladeinde AL, Arotiba JT, et al (2005). Ameloblastoma in Nigerian children and adolescents: a review of 79 cases. J Oral Maxillofac Surg, 63, 746-51.
  5. Avelar RL, Primo BT, Pinheiro-Nogueira CB, et al (2011). Worldwide incidence of odontogenic tumors. J Craniofacl Surg, 22, 2118-23. https://doi.org/10.1097/SCS.0b013e3182323cc7
  6. Bachmann AM, Linfesty RL(2009). Ameloblastoma, solid/multicystic type. Head Neck Pathol, 3, 307-9. https://doi.org/10.1007/s12105-009-0144-z
  7. Butt FM, Guthua SW, Awange DA, et al (2012). The pattern and occurrence of ameloblastoma in adolescents treated at a university teaching hospital, in Kenya: a 13-year study. J Cranio-Maxillo-Fac Surg, 40, 39-45. https://doi.org/10.1016/j.jcms.2011.03.011
  8. Chawla R, Ramalingam K, Sarkar A, et al (2013). Ninetyone cases of ameloblastoma in an Indian population: A comprehensive review. J Nat Sci Biol Med, 4, 310-5. https://doi.org/10.4103/0976-9668.116984
  9. Darshani Gunawardhana KS, Jayasooriya PR, Rambukewela IK, et al (2010).Clinico-pathological comparison between mandibular and maxillary ameloblastomas in Sri Lanka. J Oral Pathol Med, 39, 236-41. https://doi.org/10.1111/j.1600-0714.2009.00850.x
  10. Dhanuthai K, Chantarangsu S, Rojanawatsirivej S, et al (2012). Ameloblastoma: a multicentric study. Oral Surg Oral Med Oral Pathol Oral Radiol, 113, 782-8. https://doi.org/10.1016/j.oooo.2012.01.011
  11. Fregnan E, da Cruz Perez DE, de Almeida OP, et al (2010). Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas. Int J Oral Maxillofac Surg, 39, 145. https://doi.org/10.1016/j.ijom.2009.11.022
  12. Fulco GM, Nonaka CF, Souza LB, et al (2010).Solid ameloblastomas - Retrospective clinical and histopathologic study of 54 cases. Braz J Otorhinolaryngol, 76, 172-7. https://doi.org/10.1590/S1808-86942010000200005
  13. Jing W, Xuan M, Lin Y, et al (2007). Odontogenic tumours: a retrospective study of 1642 cases in a Chinese population. Int J Oral Maxillofac Surg, 36, 20-5. https://doi.org/10.1016/j.ijom.2006.10.011
  14. Kim SG, Jang H S(2001). Ameloblastoma: a clinical, radiographic, and histopathologic analysis of 71 cases. Oral Surg Oral Med Oral Patho Oral Radiol Endod, 91, 649-53. https://doi.org/10.1067/moe.2001.114160
  15. Krishnapillai R, Angadi PV (2010). A clinical, radiographic, and histologic review of 73 cases of ameloblastoma in an Indian population. Quint Int, 41, 90-100.
  16. Kumamoto H, Yamazaki S, Sato A, et al (2000). Clear cell odontogenic tumor in the mandible: report of a case with duct-like appearances and dentinoid induction. J Oral Pathol Med, 29, 43-7. https://doi.org/10.1034/j.1600-0714.2000.290108.x
  17. Ladeinde AL, Ajayi OF, Ogunlewe MO, et al (2005). A. Odontogenic tumors: a review of 319 cases in a Nigerian teaching hospital. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99, 191-5. https://doi.org/10.1016/j.tripleo.2004.08.031
  18. Ladeinde AL, Ogunlewe M O, Bamgbose BO, et al (2006). Ameloblastoma: analysis of 207 cases in a Nigerian teaching hospital. Quint Int, 37, 69-74.
  19. Lu Y, Xuan M, Takata T, et al (1998). Odontogenic tumors. A demographic study of 759 cases in a Chinese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 86, 707-14. https://doi.org/10.1016/S1079-2104(98)90208-6
  20. Manor Y, Merdinger O, Katz J, et al (1999). Unusual peripheral odontogenic tumors in the differential diagnosis of gingival swellings. J Clin Periodontol, 26, 806-9. https://doi.org/10.1111/j.1600-051X.1999.tb02524.x
  21. Mendenhall WM, Werning JW, Fernandes R, et al (2007). Ameloblastoma. Am J Clin Oncol, 30, 645-8. https://doi.org/10.1097/COC.0b013e3181573e59
  22. Mosadomi A(1975). Odontogenic tumors in an African population. Analysis of twenty-nine cases seen over a 5-year period. Oral Surg Oral Med Oral Pathol, 40, 502-21. https://doi.org/10.1016/0030-4220(75)90248-0
  23. Neville BW, Damm DD, Allen CM BJ (2009). Oral & maxillofacial pathology, 3rd ed, Saunders, 702-11.
  24. Odukoya O, Effiom OA (2008). Clinicopathological study of 100 Nigerian cases of ameloblastoma. Niger Postgrad Med J, 15, 1-5.
  25. Osterne RL, Brito RG, Alves AP, et al (2011). Odontogenic tumors: a 5-year retrospective study in a Brazilian population and analysis of 3406 cases reported in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 111, 474-81. https://doi.org/10.1016/j.tripleo.2010.10.018
  26. Razavi SM., Khazaeli A (2001). Ameloblastoma and its prevalence among patients referred to five major Iranian Dental Schools in a period of ten years (1988-1998). Shaheed Beheshti Univ Dent J, 19, 9-15.
  27. Ruhin-Poncet B, Bouattour A, Picard A, et al (2011). Ameloblastoma of the jaws. A retrospective analysis from 1994 to 2007. Rev Stomatol Chir Maxillofac, 11, 269-79.
  28. Saghravanian N, Jafarzadeh H, Bashardoost N, et al (2010). Odontogenic tumors in an Iranian population: a 30-year evaluation. J Oral Sci, 52, 391-6. https://doi.org/10.2334/josnusd.52.391
  29. Salehinejad J, Zare-Mahmoodabadi R, Saghafi S, et al (2011). Immunohistochemical detection of p53 and PCNA in ameloblastoma and adenomatoid odontogenic tumor. J Oral Sci, 53, 213-7. https://doi.org/10.2334/josnusd.53.213
  30. Siar CH, Lau SH, Ng KH (2012). Ameloblastoma of the jaws: a retrospective analysis of 340 cases in a Malaysian population. J Oral Maxillofac Surg, 70, 608-15. https://doi.org/10.1016/j.joms.2011.02.039
  31. Simon EN, Merkx MA, Vuhahula E, et al (2005). A 4-year prospective study on epidemiology and clinicopathological presentation of odontogenic tumors in Tanzania. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99, 598-602. https://doi.org/10.1016/j.tripleo.2004.10.004
  32. Taklif M, Samiee Rad F(2010). Prevalence of jaw cysts (odontogenic cysts, tumors & mesenchymal lesions) and correlation of clinicoradiopathologic features of them. Razi J Med Sci, 13, 75-81.
  33. Tamme T, Soots M, Kulla A, et al (2004). Odontogenic tumours, a collaborative retrospective study of 75 cases covering more than 25 years from Estonia. J Craniomaxillofac Surg, 32, 161-5. https://doi.org/10.1016/j.jcms.2003.12.004
  34. Tawfik MA, Zyada MM (2010). Odontogenic tumors in Dakahlia, Egypt: analysis of 82 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109, 67-73. https://doi.org/10.1016/j.tripleo.2009.07.043
  35. Vohra F, Hussain M, Mudassir M (2009). Ameloblastomas and their Management: A review. J Surg Pak, 1, 55.

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