Gallstone Etiopathogenesis, Lith and Mucin Genes and New Treatment Approaches

  • Goral, Vedat (Gastroenterology, School of Medicine, Izmir University)
  • Published : 2016.03.07


Gallstones constitute one of the more common and relatively costly conditions of the gastrointestinal system and are a major risk factor for gallbladder cancer. Most gallstone cases involve individuals younger than 60 years of age, those older representing 9% of the total in one series. There are many risk factors for gallstones and Lith and Mucin genes, for example, play important roles in their formation. Surgery is one therapeutic approach but in the future it is to be expected that drugs for prevention of gallstones will be developed in the future. This will have clear implications for gallbladder cancer control.


Gallstones;etiopathogenesis;gene involvement;therapeutic approaches


  1. Buch S, Schafmayer C, Volzke H, et al (2010). Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Gastroenterol, 139, 1942-51.
  2. Chuang SC, Hsi E, Lee KT (2012). Mucin genes in gallstone disease. Clin Chim Acta, 9, 1466-71
  3. Crawczyk M, Stokes CS, Lammert F (2013). Genetics and treatment of bile duct stones: new approaches. Curr Opin Gastroenterol, 29, 329-35
  4. De Bari O, Wang TY, Liu M, et al (2014). Cholesterol cholelithiasis in pregnant women: pathogenesis, prevention and treatment. Ann Hepatol, 13, 728-45.
  5. Di Ciaula A, Wang DQ, Garruti G, et al (2014). Therapeutic reflections in cholesterol homeostasis and gallstone disease: a review. Curr Med Chem, 21, 1435-47.
  6. Di Ciaula A, Wang DQ, Binfrate L, et al (2013). Current views on genetics and epigenetics of cholesterol gallstone disease. Cholesterol, 2013, 1-10,
  7. Di Ciaula A, Wang DQ, Wang HH, et al (2010). Targets for current pharmacologic therapy in cholesterol gallstone disease. Gastroenterol Clin North Am, 39, 245-64.
  8. Everhart JE, Khare M, Hill M, et al (1999). Prevalence and ethnic differences in gallbladder disease in the United States. Gastroenterol, 117, 632-9.
  9. Gupta S, Kori C, Kumar V, Misra S, Akhtar N (2015). Epidemiological study of gallbladder cancer patients from north Indian Gangetic planes-a high-volume centre's experience. J Gastrointest Cancer, [Epub ahead of print]
  10. Li Q, Ge X, Xu X, et al (2014). Comparison of the gene expression profiles between gallstones and gallbladder polyps. Int J Clin Exp Pathol, 15, 8016-
  11. Lyons MA, Wittenburg H (2006). Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes. Gastroenterol, 131, 1943-70.
  12. Mittal B, Mittal RD (2002). Genetics of gallstone disease. J Postgrad Med, 48, 149-52.
  13. Qiao T, Ma RH, Luo XB, et al (2013). The systematic classification of gallbladder stones. PLoS One, 4, 1-11.
  14. Rakić M, Patrlj L, Kopljar M, et al (2014). Gallbladder cancer. Hepatobiliary Surg Nutr, 3, 221-6. .
  15. Stewart L, Oesterle AL, Erdan I, et al (2002). Pathogenesis of pigment gallstones in western societies: The central role of bacteria. J Gastrointestinal Surg, 6, 891-903.
  16. Venneman NG, Van Erpecum KJ (2010). Pathogenesis of gallstones. Gastroenterol Clin Am, 39, 171-83.
  17. Wang HH, Portincasa P, Afdal NH, et al (2010). Lith genes and genetic analysis of cholesterol gallstone formation. Gastroenterol Clin North Am, 39, 185-207.
  18. Wang HH, Portincasa P, Mendez-Sanches N, et al (2008). Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterol, 134, 2101-10
  19. Yang B, Liu B, BiP, Wu T, et al (2015). An integrated analysis of differential miRNA and mRNA expressions in human gallstones. Mol Biosyst, 17, 1004-11.

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