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Association Between Liver Enzyme and Risk of All-Cause Mortality: Use of Korean Genome and Epidemiology Study (KoGES) Data

간 효소(AST, ALT)와 전체원인사망 위험의 관련성: 한국인유전체역학조사 자료 활용

  • Lee, Tae-Yong (Dept. of Preventive Medicine, Chungnam National University School of Medicine) ;
  • Ryu, Hyo-Sun (Dept. of Medical Administration & Information, Daejeon Health Institute of Technology) ;
  • Park, Chang-Soo (Dept. of Nuclear Medicine, Chungnam National University Hospital)
  • 이태용 (충남대학교 의학전문대학원 예방의학교실) ;
  • 류효선 (대전보건대학교 의무행정정보학과) ;
  • 박창수 (충남대학교 병원 핵의학과)
  • Received : 2016.08.08
  • Accepted : 2016.11.10
  • Published : 2016.11.30

Abstract

This study was conducted to investigate the association of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) with all-cause mortality among populations. The data used were from a Korean Genome and Epidemiology Study (KoGES) based on health examinations and questionnaires. The subjects consisted of 10,110 persons aged 40 and over. Hazard ratio was analyzed using Cox's proportional hazard model. The hazard ratio of AST (${\geq}50.0\;IU/L$) was 2.198 (95% CI: 1.217-3.971) after being adjusted for age, sex, education, regular exercise, smoking, drinking, WHR, and TG. In conclusion, AST was an independent significant risk factor of all-cause mortality, and ALT showed a tendency to increase. Overall, these findings indicate that AST and ALT may be useful tools for predicting mortality.

Keywords

KoGES;AST;ALT;All-cause mortality;Hazard ratio

Acknowledgement

Supported by : 충남대학교

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