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Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand

  • Tongtawee, Taweesak (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Kaewpitoon, Soraya (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Kaewpitoon, Natthawut (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Dechsukhum, Chavaboon (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Leeanansaksiri, Wilairat (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Loyd, Ryan A (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Matrakool, Likit (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Panpimanmas, Sukij (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology)
  • Published : 2016.02.05

Abstract

Background: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. Materials and Methods: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. Results: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. Conclusions: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.

Keywords

Helicobacter pylori-associated gastritis;colorectal polyps;dysplasia;risk factor

Acknowledgement

Supported by : Suranaree University of Technology

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