Immunohistochemical Evaluation of Glucose Transporter Type 1 in Epithelial Dysplasia and Oral Squamous Cell Carcinoma

  • Pereira, Karuza Maria Alves (Department of Oral Pathology, School of Dentistry, Federal University of Ceara - Campus Sobral) ;
  • Feitosa, Sthefane Gomes (Department of Oral Pathology, School of Dentistry, Federal University of Ceara - Campus Sobral) ;
  • Lima, Ana Thayssa Tomaz (Department of Oral Pathology, School of Dentistry, Federal University of Ceara - Campus Sobral) ;
  • Luna, Ealber Carvalho Macedo (Department of Oral Pathology, School of Dentistry, Federal University of Ceara - Campus Sobral) ;
  • Cavalcante, Roberta Barroso (Department of Oral Pathology, Fortaleza University) ;
  • Lima, Kenio Costa de (Department of Social and Preventive Odontology, School of Dentistry, Federal University of Rio Grande do Norte) ;
  • Chaves, Filipe Nobre (Department of Oral Pathology, School of Dentistry, Federal University of Ceara - Campus Sobral) ;
  • Costa, Fabio Wildson Gurgel (Department of Clinical Dentistry, School of Dentistry, Federal University of Ceara)
  • Published : 2016.02.05


Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and some of these have been documented in association or preceded by oral epithelial dysplasia (OED). Aggressive cancers with fast growth have demonstrated overexpression of some glucose transporters (GLUTs). Thus, the aim of this study was to analyze the immunohistochemical expression of the glucose transporter, GLUT-1, in OEDs and OSCCs, seeking to better elucidate the biological behavior of neoplasias. Fifteen cases were selected this research of both lesions. Five areas were analyzed from each case by counting the percentage of positive cells at 400x magnification. Immunoreactivity of GLUT-1 was observed in 100% of the samples ranging from 54.2% to 86.2% for the OSCC and 73.9% to 97.4% for the OED. Statistical test revealed that there was greater overexpression of GLUT-1 in OED than the OSCC (p=0.01). It is believed the high expression of GLUT-1 may reflect the involvement of GLUT-1 in early stages of oral carcinogenesis.


Oral squamous cell carcinoma;oral epithelaial dysplaisa;GLUT;immunohistochemistry


Supported by : Fundacao Cearense de Apoio ao Desenvolvimento Cientifico e Tecnologico


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