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Are p53 Antibodies a Diagnostic Indicator for Patients with Oral Squamous Cell Carcinoma? Systematic Review and Meta-Analysis

  • Yang, Zhi-Cheng (Department of Oral Maxillary Facial Surgery, Yantai Affiliated Hospital of Binzhou Medical University) ;
  • Ling, Li (Department of Public Health, Binzhou Medical University) ;
  • Xu, Zhi-Wei (Department of Medical Quality Control, 302 PLA hospital) ;
  • Sui, Xiao-Dong (Department of School of Dentistry, Binzhou Medical University) ;
  • Feng, Shuang (Department of School of Dentistry, Binzhou Medical University) ;
  • Zhang, Jun (Department of Scientific Research and Teaching, Yantai Affiliated Hospital of Binzhou Medical University)
  • Published : 2016.02.05

Abstract

Background: P53 has been reported to be involved with tumorigenesis and has also been implicated as a significant biomarker in oral squamous cell carcinoma(OSCC). However, the diagnostic value of p53 antibodies remains controversial; hence, we comprehensively and quantitatively assessed the potential in the present systematic review. Materials and Methods: A comprehensive search was performed using PubMed and Embase, up to October 31, 2014, without language restriction. Studies were assessed for quality using QUADAS (quality assessment of studies of diagnostic accuracy). The positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were pooled separately and compared with overall accuracy measures using diagnostic odds ratios (DORs) and symmetric summary receiver operating characteristic (SROC) curves. Results: Of 150 studies initially identified, 7 eligible regarding serum p53 antibodies met the inclusion criteria. Some 85.7% (6/7) were of relatively high quality (QUADAS $score{\geq}7$). The summary estimates for quantitative analysis of serum p53 antibody in the diagnosis of squamous cell carcinoma were: PLR 2.06 [95% confidence interval (CI) : 1.35-3.15], NLR 0.85 (95%CI: 0.80-0.90) and DOR 2.47 (95%CI: 1.49-4.12). Conclusions: This meta-analysis suggests that the use of s-p53-antibodies has potential diagnostic value with relatively high sensitivity and specificity for OSCC particularly with serum specimens for discrimination of OSCCs from healthy controls. However, its discrimination power is not perfect because of low sensitivity.

Keywords

OSCC;diagnosis;P53 antibodies;serum biomarker;meta-analysis

Acknowledgement

Supported by : Natural Science Foundation of Shandong Province

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