Evaluation of the Histo-Epidemiological Profile of Solid Childhood Cancers in Togo

  • Darre, Tchin (Department of Pathology, University Teaching Hospital of Lome) ;
  • Maneh, Nidain (Department of Ophthalmology, University Teaching Hospital of Lome) ;
  • Kpatcha, Matchonna (Department of Urology, University Teaching Hospital of Lome) ;
  • Boume, Azanledji (Department Pediatric Surgery, University Teaching Hospital of Lome) ;
  • Padaro, Essohana (Department of Hematology, University Teaching Hospital of Lome) ;
  • Amegbor, Koffi (Department of Pathology, University Teaching Hospital of Lome) ;
  • Napo-Koura, Gado (Department of Pathology, University Teaching Hospital of Lome)
  • Published : 2016.02.05


Background: Cancer is a subject of continuing concern, more common in adults than in children, but often with a poor outcome in the latter. Our study set itself the objective to describe the epidemiological and histological aspects of solid cancers in children in Togo. Materials and Methods: This descriptive, cross-sectional study focused on cases of solid cancers in children diagnosed from 2010 to 2014 (5 years) at the pathology laboratory of the Tokoin teaching hospital. Data were collected from the records of that laboratory. Results: We collected 66 cases of childhood cancer representing 5% of all solid cancers. The annual incidence was 13.2 cases. The sex ratio (M/F) was 1.4; mean age was of $7.2{\pm}1.6years$. The age group most affected was that of 5-9 years (40.9%). Four histological groups of solid childhood cancers were listed: lymphoma (n=34 cases; 51.5%), embryonic cancer (n=17 cases; 25.8%), sarcomas (n=13 cases; 19.7%) and carcinoma (n=2 cases; 3%). The most common histological types were Burkitt lymphoma (36.4%), nephroblastoma (10.6%) and retinoblastoma (10.6%). Conclusions: This study shows that solid cancers in children are relatively frequent in Togo with a male predominance. They are still largely dominated by Burkitt lymphoma, followed by retinoblastoma and nephroblastoma.


Solid cancers;childhood;epidemiology;histology;Togo


  1. Lacour B, Guyot-Goubin A, Guissou S, et al (2010) Incidence of childhood cancer in France: National Children Cancer Registries, 2000-2004. Eur J. Cancer Prev, 19, 173-81.
  2. Mukiibi JM, Banda L, Liomba NG, et al (1995) Spectrum of childhood cancers in Malawi from 1985 to 1993. East Afr J Med, 72, 25-9.
  3. Packer RJ, Mac Donald T, Vezina G. (2010) Central nervous system tumors. Hematol Oncol Clin North Am, 24, 87-108.
  4. Peko JF, Middle G, Gombe-Mbabwa C (2004) Child solid tumors in Brazzaville: epidemiological and pathological aspects. Bull Soc Pathol Exot, 97, 117-8
  5. Tanko SL, Echejoh GO, Manasseh NA, et al (2009) Mandong MB, Uba AF. Paediatric Solid Tumours in Nigerian children: a changing pattern? Paediatr Afr J Surg, 6, 7-10.
  6. Valery PC, Moore SP, Meiklejohn J, Bray F (2014) International variations in childhood cancer in indigenous populations: a systematic review. Lancet Oncol, 15, 90-103.
  7. Icher BC, Colin MV, Isopof A, et al (2006) Hartmann solid tumors neonatal about 71 cases. Pediatric Archives, 13, 1486-96.
  8. Akhiwu WO, Igbe AP, Aligbe JU, et al (2009) Malignant Tumours in childhood solid Benin City, Nigeria. West Afr J Med, 28, 222-6.
  9. Akinde OR, Abdukareem FB, Daramola AO, et al (2009) Morphological pattern of childhood Solid Tumours in Lagos University Teaching Hospital. Nig Q J Hosp Med, 19, 169-74.
  10. Amegbor K, Darre T, Padaro E, et al (2011) Childhood solid cancers in Togo: epidemiologic and pathologic features about 365 boxes Observed in the Tokoin teaching hospital of Lome. J Afr Cancer, 3, 24-8.
  11. Bao PP, Li K, Wu CX, et al (2013) Recent incidences and trends of childhood malignant solid tumors in Shanghai, 2002-2010. Zhonghua Er Ke Za Zhi, 51, 288-94
  12. Bergeron C, Philip T (2004) Cancer in children: epidemiological, diagnostic and therapeutic. Review Practitioner, 54, 1489-95
  13. Bonet-Peris R, Martinez-Garcia C, Lacour B, et al (2006) Childhood central nervous system Tumours-incidence and survival in Europe (1978-1997): report from Automated Childhood Cancer Information System project. Eur J Cancer, 42, 2064-80
  14. Correa P, O'Conor GT. (2006) Epidemiologic patterns of Hodgkin's Disease. Int J Cancer, 8, 192-201
  15. Desandes E, Clavel, J, Berger C (2004) Cancer incidence Among children in France, 1990-1999. Pediatr Blood Cancer, 43, 749-57
  16. Effi AB, Aman NA, Koffi KD, et al (2012) Solid Childhood cancer in Cote d'Ivoire: a study of 556 cases. J Afr Cancer, 4, 204-8
  17. Foucher-Steliarova E, Stiller C, Lacour B, Kaatsch P (2005) International classification of childhood cancer, Third Edition. Cancer, 103, 1457-67
  18. Grimer RJ. (2005) Surgical options for children with osteosarcoma. Lancet Oncol, 6, 85-92.
  19. Hadley LG, Rouma BS, Eldin Saad Y (2012) Challenge of pediatric oncology in Africa. Semin Pediatr Surg, 21, 136-41.
  20. Hochberg J, Waxman IM, Kelly KM, et al (2009) Non-hodgkin lymphoma and hodgkin lymphoma teenager: state of the science. Br J Haematol, 144, 24-40.