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Inhibitory Effects of Gosambaeksunpibokhap-bang(GBBB) Extract in an Atopic Dermatitis Animal Model

아토피 동물모델에서 고삼백선피복합방(GBBB)의 아토피 억제효과

  • 이다영 (대전대학교 뷰티건강관리학과) ;
  • 승윤철 (중부대학교 한방건강관리학과) ;
  • 정규진 (충남대학교 약학과)
  • Received : 2016.09.12
  • Accepted : 2016.11.20
  • Published : 2016.11.28

Abstract

In order to clarify the Gosambaeksunpibokhap-bang(GBBB)'s therapeutic possibility on atopic dermatitis (AD), influences of GBBB on the changes of various immune-related factors and histological changes in NC/Nga mice were evaluated. Experimental results are as follows. Sign of recovery from AD was observed in GBBB treated group with naked eye test. The ratio of white blood cells, neutrophil, lymphocytes, monocyte in blood were decreased to 54%, 63%, 57% and 86% respectively in the GBBB group. IL-4, IL-5, IL-13, Histamine and IgE were significantly decreased to 40%, 80%, 62%, 61% and 57% respectively in the GBBB group. H&E staining showed thickness of epidermis and dermis were decreased by GBBB and inhibited the infiltration of lymphocytes. On the basis of these results, GBBB was confirmed that the possibility as an AD treatment applied externally to the skin. In the further study, immune control mechanism of GBBB will be demonstrated through the additional molecular biological research.

Keywords

Atopic dermatitis(AD);NC/Nga mouse;IgE;Histamine;Mast cell

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