- Volume 10 Issue 6
DOI QR Code
High maysin corn silk extract reduces body weight and fat deposition in C57BL/6J mice fed high-fat diets
- Lee, Eun Young ;
- Kim, Sun Lim ;
- Kang, Hyeon Jung ;
- Kim, Myung Hwan ;
- Ha, Ae Wha ;
- Kim, Woo Kyoung
- Received : 2016.05.16
- Accepted : 2016.08.09
- Published : 2016.12.01
BACKGROUNG/OBJECTIVES: The study was performed to investigate the effects and mechanisms of action of high maysin corn silk extract on body weight and fat deposition in experimental animals. MATERIALS/METHODS: A total of 30 male C57BL/6J mice, 4-weeks-old, were purchased and divided into three groups by weight using a randomized block design. The normal-fat (NF) group received 7% fat (diet weight basis), the high-fat (HF) group received 25% fat and 0.5% cholesterol, and the high-fat corn silk (HFCS) group received high-fat diet and high maysin corn silk extract at 100 mg/kg body weight through daily oral administration. Body weight and body fat were measured, and mRNA expression levels of proteins involved in adipocyte differentiation, fat accumulation, fat synthesis, lipolysis, and fat oxidation in adipose tissue and the liver were measured. RESULTS: After experimental diet intake for 8 weeks, body weight was significantly lower in the HFCS group compared to the HF group (P < 0.05), and kidney fat and epididymal fat pad weights were significantly lower in the HFCS group compared to the HF group (P < 0.05). In the HFCS group, CCAAT/enhancer binding protein-
Corn silk;maysin;Body weight;adipocyte differentiation;fat synthesis
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Grant : Cooperative Research Program for Agriculture Science & Technology Developmen
Supported by : Rural Development Administration