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Simple and Ultrasensitive Chemically Amplified Electrochemical Detection of Ferrocenemethanol on 4-Nitrophenyl Grafted Glassy Carbon Electrode

  • Koh, Ahyeon (Department of Chemistry and Biomedical Engineering, Sogang University) ;
  • Lee, Junghyun (Department of Chemistry and Biomedical Engineering, Sogang University) ;
  • Song, Jieun (Department of Chemistry and Biomedical Engineering, Sogang University) ;
  • Shin, Woonsup (Department of Chemistry and Biomedical Engineering, Sogang University)
  • Received : 2016.10.28
  • Accepted : 2016.10.29
  • Published : 2016.12.31

Abstract

Chemically amplified electrochemical detection, redox-active probe being amplified its electrochemical anodic current by a sacrificial electron donor presenting in solution, holds great potential for simple and quantitative bioanalytical analysis. Herein, we report the chemically amplified electrochemical analysis that drastically enhanced a detection of ferrocenemethanol (analyte) by ferrocyanide (chemical amplifier) on 4-nitrophenyl grafted glassy carbon electrodes at $60^{\circ}C$. The glassy carbon electrode grafted with a 4-nitrophenyl group using an electrochemical reduction suppressed the oxidation of ferrocyanide and thus enabled detection of ferrocenemethanol with excellent selectivity. The ferrocenemethanol was detected down to an nM range using a linear sweep voltammetry under kinetically optimized conditions. The detection limit was improved by decreasing the concentration of the ferrocyanide and increasing temperature.

Acknowledgement

Supported by : National Research Foundation (NRF)

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