Effect of task-specific training on Eph/ephrin expression after stroke

  • Choi, Dong-Hee (Department of Medical Science, Konkuk University School of Medicine) ;
  • Ahn, Jin-Hee (Department of Medical Science, Konkuk University School of Medicine) ;
  • Choi, In-Ae (Department of Medical Science, Konkuk University School of Medicine) ;
  • Kim, Ji-Hye (Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University) ;
  • Kim, Bo-Ram (Department of Rehabilitation Medicine, Konkuk University School of Medicine) ;
  • Lee, Jongmin (Department of Rehabilitation Medicine, Konkuk University School of Medicine)
  • Received : 2016.10.09
  • Accepted : 2016.10.17
  • Published : 2016.11.30


Recent evidence indicates that the ephrin receptors and ephrin ligands (Eph/ephrin) expression modulate axonal reorganization and synaptic plasticity in stroke recovery. To investigate the effect of task-specific training (TST) on Eph/ephrin expression in the corticospinal tract (CST) after stroke, we compared Eph/ephrin expression in the peri-infarct cortex, pyramid, and spinal cord of a photothrombotic stroke model of rat brains treated with or without TST. The TST treatment showed significantly better recovery in the behavioral tests compared with no treatment. The significant upregulation of ephrin-A1 and ephrin-A5 observed in activated astrocytes of the CST at 2 weeks' post-stroke was decreased by TST. At 5 weeks, post-stroke, the elevated ephrin-A5 levels were decreased in the ipsilateral pyramid and spinal cord by TST. Glial fibrillary acidic protein was upregulated concomitantly with the altered ephrin expression after stroke, and the expression of these proteins was attenuated by TST. These data suggest that TST alters the expression of ephrin ligands in the CST after stroke.


Eph/ephrin expression;Reactive astrocytes;Stroke;Stroke recovery;Task-specific training


Supported by : National Research Foundation of Korea(NRF), Korea Health Industry Development Institute (KHIDI)


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