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Evaluation Frequency of Merkel Cell Polyoma, Epstein-Barr and Mouse Mammary Tumor Viruses in Patients with Breast Cancer in Kerman, Southeast of Iran

  • Reza, Malekpour Afshar (Kerman University of Medical sciences, Afzalipour School of Medicine, Research Center of Infectious and Tropical Diseases) ;
  • Reza, Mollaie Hamid (Medical Virology, Gastrointestinal and Liver Research center, Department of Medical Virology, Kerman University of Medical Sciences) ;
  • Mahdiyeh, Lashkarizadeh (Pathology and stem cell research center, Kerman University of Medical sciences) ;
  • Mehdi, Fazlalipour (Medical Virology, Department of Arboviruses, Institute of pasture) ;
  • Hamid, Zeinali Nejad (Kerman University of Medical sciences, Afzalipour School of Medicine, Department of Phisiology)
  • Published : 2015.11.04

Abstract

Breast cancer is the most common cancer among women worldwide. Roles of the Epstein-Barr, Merkel cell polyoma and mouse mammary tumor viruses in breast carcinogenesis are still controversial although any relationship would clearly be important for breast cancer etiology, early detection and prevention. In the present study associations between EBV, MMTV and Merkel cell polyoma virus and breast cancer in 100 Iranian patients were evaluated using paraffin-embedded tissues. EBER RNA and expression of p53 and large T antigen were evaluated by real time PCR and CD34, p63, HER2, PR and ER markers were studied by immunohistochemistry. EBV was detected in 8/100 (8%), MMTV in 12/100 (12%), MPy in 3/100 (3%) and EBER RNA in 18/100 (18%) cases. None of the control samples demonstrated any of the viruses. p53 was suppressed in EBV, MPy and MMTV positive samples. The large T antigen rate was raised in MPy positive samples. Our results showed that EBV, MMTV and the Merkel cell polyoma virus are foundwith some proportion of breast cancers in our patients, suggesting that these viruses might have a significant role in breast cancer in Kerman, southeast of Iran.

Keywords

Breast cancer;Epstein-Barr virus;Merkel cell polyoma virus;mouse mammary tumor virus

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