Quantitative Analysis of Enlarged Cervical Lymph Nodes with Ultrasound Elastography

  • Zhang, Jun-Peng (Department of Ultrasonography, the Affiliated Hospital of Qingdao University) ;
  • Liu, Hua-Yan (Department of Ultrasonography, the Affiliated Hospital of Qingdao University) ;
  • Ning, Chun-Ping (Department of Ultrasonography, the Affiliated Hospital of Qingdao University) ;
  • Chong, Jing (Department of Ultrasonography, the Affiliated Hospital of Qingdao University) ;
  • Sun, Yong-Mei (Department of Ultrasonography, the Affiliated Hospital of Qingdao University)
  • Published : 2015.11.04


Purpsoe: To investigate the diagnostic value of quantitative analysis of a tissue diffusion and virtual touch tissue imaging quantification (VTIQ) technique with acoustic radiation force impulse (ARFI) elastography for assessing enlarged cervical lymph nodes. Materials and Methods: Fifty-six enlarged cervical lymph nodes confirmed by pathologic diagnoses were covered in the study. According to the results of pathologic diagnosis, patients were classified into benign and malignant groups. All the patients were examined by both conventional ultrasonography and elastography. AREA% and shear wave velocity (SWV) in ROI of different groups were calculated and compared using ROC curves. Cut-off points of AREA% and SWV were determined with receiver operating characteristic curves. Results: Final histopathological results revealed 21 cases of benign and 35 cases of malignant lymph nodes. The mean values of AREA% and SWV in benign and malignant groups were $45.0{\pm}17.9%$ and $2.32{\pm}0.57m/s$, and $61.3{\pm}21.29%$ and $4.36{\pm}1.25$)m/s, respectively. For the parameters of elastography, "AREA%" and SWV demonstrated significant differences between groups (p=0.002). AREA% was positively correlated with SWV with a correlation coefficient of 0.809 (P<0.001). Conclusions: Stiffness of different lymph node diseases in patients may differ. Elastography can evaluate changes sensitively and provide valuable information to doctors. The study proved that the VTIQ elastography technique can play an important role in differential diagnosis of lymph nodes.


Elasticity imaging techniques;virtual touch tissue imaging;lymphadenopathy


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