- Volume 16 Issue 16
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Multi-Parameter Approach for Evaluation of Genomic Instability in the Polycystic Ovary Syndrome
- Sekar, Nishu (Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University) ;
- Nair, Manju (Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University) ;
- Francis, Glory (Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University) ;
- Kongath, Parvathy Raj (Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University) ;
- Babu, Sandhya (Sandhya Hospital) ;
- Raja, Sudhakaran (Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University) ;
- Gopalakrishnan, Abilash Valsala (Division of Biomolecules and Genetics, School of Biosciences and Technology, VIT University)
- Published : 2015.11.04
Background: The polycystic ovary syndrome (PCOS), characterized by hyperandrogenism and chronic anovulation, is a common endocrine disorder in women. PCOS, which is associated with polycystic ovaries, hirsutism, obesity and insulin resistance, is a leading cause of female infertility. In this condition there is an imbalance in female sex hormones. All the sequelae symptoms of PCOS gradually lead to cancer in the course of time. It is heterogeneous disorder of unknown etiology so it is essential to find the exact cause. Materials and Methods: In this study both invasive and non-invasive techniques were employed to establish the etiology. Diagnosis was based on Rotterdam criteria (hyperandrogenism, ovulatory dysfunction, PCOM) and multiparameters using buccal samples and dermatoglypic analysis and cytogenetic study for 10 cases and four age and sex matched controls. Results: In clinical analysis we have observed the mean value of total testosterone level was 23.6nmol/L, total hirsutism score was from 12-24, facial acne was found in in 70% patients with 7-12 subcapsular follicular cysts, each measuring 2-8 mm in diameter. In dermatoglypic analysis we observed increases in mean value (
Polycystic ovary syndrome;cytogenetic;dermatoglypics;buccal micronuclei analysis
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