Effects of Home Nursing Intervention on the Quality of Life of Patients with Nasopharyngeal Carcinoma after Radiotherapy and Chemotherapy

  • Shi, Ru-Chun (Outpatient of Oncology Nursing, Jiangsu Cancer Hospital) ;
  • Meng, Ai-Feng (Nursing Department, Jiangsu Cancer Hospital) ;
  • Zhou, Weng-Lin (Department of Radiotherapy, Jiangsu Cancer Hospital) ;
  • Yu, Xiao-Yan (Department of Radiotherapy, Jiangsu Cancer Hospital) ;
  • Huang, Xin-En (Department of Medical Oncology, Jiangsu Cancer Hospital) ;
  • Ji, Ai-Jun (Department of Analgesia, Jiangsu Cancer Hospital) ;
  • Chen, Lei (Department of Oncology, Nantong Cancer Hospital)
  • Published : 2015.11.04


Background: The effects of home nursing intervention on the quality of life in patients with nasopharyngeal carcinoma (NPC) after radiotherapy and chemotherapy are unclear. According to the characteristics of nursing home patients with nasopharyngeal carcinoma, we should continuously improve the nursing plan and improve the quality of life of patients at home. Materials and Methods: We selected 180 patients at home with NPC after radiotherapy and chemotherapy. The patients were randomly divided into experimental and control groups (90 patients each). The experimental group featured intervention with an NPC home nursing plan, while the control group was given routine discharge and outpatient review. Nursing intervention for patients was mainly achieved by regular telephone follow-up and home visits. We use the quality of life scale (QOL-C30), anxiety scale (SAS) and depression scale (SDS) to evaluate these patients before intervention, and during follow-up at 1 month and 3 months after the intervention. Results: Overall health and quality of life were significantly different between the groups (p<0.05), Emotional function score was significantly higher after intervention (p<0.05), as were cognitive function and social function scores after 3 months of intervention (p<0.05). Scores of fatigue, nausea and vomiting, pain, appetite and constipation were also significantly different between the two groups (p<0.05). Rates of anxiety and depression after 3 months of intervention were 11.1%, 22.2% and 34.4%, 53.3%, the differences being significant (p<0.05). Conclusions: NPC home nursing plan could effectively improve overall quality of life, cognitive function, social function (after 3 months) of patients, but improvement regarding body function is not suggested. Fatigue, nausea and vomiting, pain, appetite, constipation were clearly improved. We should further pursue a personalized, comprehensive measurements for nursing interventions and try to improve the quality of life of NPC patients at home.


Home nursing;intervention;NPC;radiotherapy and chemotherapy;quality of life;China


  1. Bei JX, Li Y, Jia WH, et al (2010). A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci, Nat Genet, 42, 599-603
  2. Fang FM, Tsai WL, Ko SF, et al (2001). Implications of quantitative tumor and nodal regression rates for nasopharyngeal carcinomas after 45 Gy of RT. Int J Radiat Oncol Biol Phys, 50, 961-9.
  3. Fang FM, Leung SW, Wang CJ, et al (1999). Computed tomography findings of bony regeneration after RT for nasopharyngeal carcinoma with skull base destruction: implications for local control. Int J Radiat Oncol Biol Phys, 44, 305-09.
  4. He G, Liu S (2005). Quality of life and coping styles in chinese nasopharyngeal cancer patients after hospitalization. Cancer Nursing, 28, 179-86.
  5. Hong JS, Tian J, Han QF, et al (2015). Quality of life of nasopharyngeal cancer survivors in China. Current Oncol, 22, 142-7.
  6. Huguenin PU, Taussky D, Moe K, et al (1999). Quality of life in patients cured from a carcinoma of the head and neck by radiotherapy, the importance of the target volume. Head Neck, 45, 47-52.
  7. Hughes PJ, Scott PM, Kew J (2000). Dysphasia in treated nasopharyngeal cancer. Head Neck, 22, 393-7.<393::AID-HED13>3.0.CO;2-2

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