Association between p16 Promoter Methylation and Thyroid Cancer Risk: A Meta-analysis

  • Wu, Wei (Laboratory of Molecular Genetics of Aging & Tumor, Faculty of Medicing, Kunming University of Science and Technology) ;
  • Yang, Sheng-Fu (Department of Pharmacy, The First People's Hospital of Yunnan Province) ;
  • Liu, Fei-Fei (Laboratory of Molecular Genetics of Aging & Tumor, Faculty of Medicing, Kunming University of Science and Technology) ;
  • Zhang, Ji-Hong (Laboratory of Molecular Genetics of Aging & Tumor, Faculty of Medicing, Kunming University of Science and Technology)
  • Published : 2015.11.04


Background: The aim of the meta-analysis was to derive a more precise assessment of the association between p16 promoter methylation and thyroid cancer risk. Materials and Methods: The PubMed, Web of Science databases and Chinese CNKI were searched for relevant articles. Ultimately, seventeen case-control studies were included with a total of 804 thyroid cancer cases and 487 controls analysis by R Software (R version 3.1.2) including meta. Crude odds ratios with 95% confidence intervals were calculated using the random-effects model which were used to assess the strength of relationship between p16 methylation and lung carcinogenesis. Funnel plots were carried out to evaluate publication bias. Results: The meta-analysis results showed that the frequency of p16 promoter methylation in cancer tissue/blood was significantly higher than that normal tissue/blood (OR=5.46, 95%CI 3.12-9.55, P<0.0001) by random effects model with small heterogeneity. Conclusions: Thus, p16 promoter methylation may be associated with thyroid cancer risk.


Thyroid cancer;p16 promoter methylation;Meta-analysis


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