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Outcome of Palliative and Radical Radiotherapy in Patients with Oral Squamous Cell Carcinoma - a Retrospective Study

  • Rai, Narendra Prakash (Department of Oral Medicine and Radiology, Lincoln's University College) ;
  • Divakar, Darshan Devang (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) ;
  • Al Kheraif, Abdulaziz Abdullah (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) ;
  • Ramakrishnaiah, Ravikumar (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) ;
  • Mustafa, Shabil Mohamed (Department of Oral Medicine and Radiology, Malabar Dental College and Research Centre) ;
  • Durgesh, BH (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) ;
  • Basavarajappa, Santhosh (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University) ;
  • Khan, Aftab Ahmed (Dental Biomaterials Research Chair, College of Applied Medical Sciences, King Saud University)
  • Published : 2015.11.04

Abstract

Background: The treatment selection for the oral squamous cell carcinoma remains controversial. Radiation therapy or surgical excision of the lesion can be applied as the sole treatment or it can be used in combination with other treatment modalities. Radiotherapy is considered to be the safest of all the treatment modalities and can be used in several situations for oral and oropharyngeal cancers. The aim of this study was to evaluate the survival outcome differences in patients treated with radical and palliative radiotherapy as the primary treatment modality. Materials and Methods: The study included a total of 47 patients with oral cancer reporting to our hospital between years 2009 to 2010. The age group for the selected patients was more than 65 years, treated with radical and palliative radiotherapy with no prior surgical interventions. Patients were evaluated till Dec 2013 for overall survival time. Results: Twenty nine patients were treated with radical radiotherapy as main stay of treatment, out of which 21 died during the follow up time with median survival of $352{\pm}281.7$ days with 8 patients alive. All the 16 patients were dead who received palliative radiotherapy with a median survival time of $112{\pm}144.0$ days. Conclusions: This retrospective study showed improved overall survival time, loco regional control rates and reduced morbidity in patients treated with radical radiotherapy when compared to patients treated with palliative radiotherapy.

Keywords

Long term survival;oral cancer;palliative radiotherapy;radical radiotherapy

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