DOI QR코드

DOI QR Code

Meningeal Hemangiopericytomas and Meningomas: a Comparative Immunohistochemical and Genetic Study

  • Trabelsi, Saoussen (Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital) ;
  • Mama, Nadia (Department of Imagery, Sahloul University Hospital) ;
  • Chourabi, Maroua (Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital) ;
  • Mastouri, Maroua Haddaji (Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital) ;
  • Ladib, Mohamed (Department of Neuro-Surgery, Sahloul University Hospital) ;
  • Popov, Sergey (Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research) ;
  • Burford, Anna (Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research) ;
  • Mokni, Moncef (Department of Histopathology-Cytopathology, Farhat Hached University Hospital) ;
  • Tlili, Kalthoum (Department of Imagery, Sahloul University Hospital) ;
  • Krifa, Hedi (Department of Neuro-Surgery, Sahloul University Hospital) ;
  • Jones, Chris (Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research) ;
  • Yacoubi, Mohamed Tahar (Department of Histopathology-Cytopathology, Farhat Hached University Hospital) ;
  • Saad, Ali (Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital) ;
  • Brahim, Dorra H'mida-Ben (Department of Cytogenetics, Molecular Genetics and Reproductive Biology, Farhat Hached University Hospital)
  • Published : 2015.11.04

Abstract

Background: The meningeal hemangiopericytoma (MHPC) is a vascular tumor arising from pericytes. Most intracranial MHPCs resemble meningiomas (MNGs) in their clinical presentation and histological features and may therefore be misdiagnosed, despite important differences in prognosis. Materials and Methods: We report 8 cases of MHPC and 5 cases of MNG collected from 2007 to 2011 from the Neuro-Surgery and Histopathology departments. All 13 samples were re reviewed by two independent pathologists and investigated by immunohistochemistry (IHC) using mesenchymal, epithelial and neuro-glial markers. Additionally, we screened all tumors for a large panel of chromosomal alterations using multiplex ligation probe amplification (MLPA). Presence of the NAB2-STAT6 fusion gene was inferred by immunohistochemical staining for STAT6. Results: Compared with MNG, MHPCs showed strong VIM (100% of cases), CD99 (62%), bcl-2 (87%), and p16 (75%) staining but only focal positivity with EMA (33%) and NSE (37%). The p21 antibody was positive in 62% of MHPC and less than 1% in all MNGs. MLPA data did not distinguish HPC from MNG, with PTEN loss and ERBB2 gain found in both. By contrast, STAT6 nuclear staining was observed in 3 MHPC cases and was absent from MNG. Conclusions: MNG and MHPC comprise a spectrum of tumors that cannot be easily differentiated based on histopathology. The presence of STAT6 nuclear positivity may however be a useful diagnostic marker.

Keywords

Meningeal hemangiopericytoma;immunohistochemistry;NAB2-STAT6 fusion;molecular analysis

References

  1. Abrahams JM, Forman MS, Lavi E, et al (1999). Hemangiopericytoma of the third ventricle. Case report. J Neurosurg, 90, 359-62. https://doi.org/10.3171/jns.1999.90.2.0359
  2. Akiyama M, Sakai H, Onoue H, et al (2004). Imaging intracranial haemangiopericytomas: study of seven cases. Neuroradiol, 46, 194-7. https://doi.org/10.1007/s00234-003-1157-z
  3. Alen JF, Lobato RD, Gomez PA, et al (2001). Intracranial hemangiopericytoma: study of 12 cases. Acta Neurochir (Wien), 143, 575-86. https://doi.org/10.1007/s007010170062
  4. Barthelmess S, Geddert H, Boltze C, et al (2014). Solitary fibrous tumors/hemangiopericytomas with different variants of the NAB2-STAT6 gene fusion are characterized by specific histomorphology and distinct clinicopathological features. Am J Pathol, 184, 1209-18. https://doi.org/10.1016/j.ajpath.2013.12.016
  5. Bostrom J, Meyer-Puttlitz B, Wolter M, et al (2001). Alterations of the tumor suppressor genes CDKN2A (p16(INK4a)), p14(ARF), CDKN2B (p15(INK4b)), and CDKN2C (p18(INK4c)) in atypical and anaplastic meningiomas. Am J Pathol, 159, 661-9. https://doi.org/10.1016/S0002-9440(10)61737-3
  6. Chan JK, Cheuk W, Ho LC, et al (2012). Recurrent meningeal hemangiopericytoma with multiple metastasis and hypoglycemia: a case report. Case Rep Med, 2012, 628756.
  7. Chiechi MV, Smirniotopoulos JG, Mena H (1996). Intracranial hemangiopericytomas: MR and CT features. AJNR Am J Neuroradiol, 17, 1365-71.
  8. de Bont JM, Packer RJ, Michiels EM, et al (2008). Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective. Neuro Oncol, 10, 1040-60. https://doi.org/10.1215/15228517-2008-059
  9. Elenius K, Choi CJ, Paul S, et al (1999). Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. Oncogene, 18, 2607-15. https://doi.org/10.1038/sj.onc.1202612
  10. Gilbertson RJ, Clifford SC, MacMeekin W, et al (1998). Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma. Cancer Res, 58, 3932-41.
  11. Guthrie BL, Ebersold MJ, Scheithauer BW, et al (1989). Meningeal hemangiopericytoma: histopathological features, treatment, and long-term follow-up of 44 cases. Neurosurg, 25, 514-22. https://doi.org/10.1227/00006123-198910000-00003
  12. Iwaki T, Fukui M, Takeshita I, et al (1988). Hemangiopericytoma of the meninges: a clinicopathologic and immunohistochemical study. Clin Neuropathol, 7, 93-9.
  13. Jazayeri SB, Rahimi-Movaghar V, Shokraneh F, et al (2013). Epidemiology of primary CNS tumors in Iran: a systematic review. Asian Pac J Cancer Prev, 14, 3979-85. https://doi.org/10.7314/APJCP.2013.14.6.3979
  14. Kuzeyli K, Cakir E, Karaarslan G, et al (2003). Primary parenchymal cerebral cystic haemangiopericytoma: a 5-year follow up of disease progression. Australas Radiol, 47, 88-91. https://doi.org/10.1046/j.1440-1673.2003.01114.x
  15. Larijani L, Madjd Z, Samadikuchaksaraei A, et al (2014). Methylation of O6-methyl guanine methyltransferase gene promoter in meningiomas--comparison between tumor grades I, II, and III. Asian Pac J Cancer Prev, 15, 33-8. https://doi.org/10.7314/APJCP.2014.15.1.33
  16. Muttaqin Z, Uozumi T, Kuwabara S, et al (1991). Intraventricular hemangiopericytoma--case report. Neurol Med Chir (Tokyo), 31, 662-5. https://doi.org/10.2176/nmc.31.662
  17. Ozbayir T, Malak AT, Bektas M, et al (2011). Information needs of patients with meningiomas. Asian Pac J Cancer Prev, 12, 439-41.
  18. Peters N, Wellenreuther R, Rollbrocker B, et al (1998). Analysis of the PTEN gene in human meningiomas. Neuropathol Appl Neurobiol, 24, 3-8. https://doi.org/10.1046/j.1365-2990.1998.00093.x
  19. Rajaram V, Brat DJ, Perry A (2004). Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers. Hum Pathol, 35, 1413-8. https://doi.org/10.1016/j.humpath.2004.07.017
  20. Schweizer L, Koelsche C, Sahm F, et al (2013). Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein. Acta Neuropathol, 125, 651-8. https://doi.org/10.1007/s00401-013-1117-6
  21. Shoji T, Tanaka F, Takata T, et al (2002). Clinical significance of p21 expression in non-small-cell lung cancer. J Clin Oncol, 20, 3865-71. https://doi.org/10.1200/JCO.2002.09.147
  22. Stout AP, Murray MR (1942). Hemangiopericytoma: a vascular tumor featuring zimmermann’s pericytes. Ann Surg, 116, 26-33. https://doi.org/10.1097/00000658-194207000-00004
  23. Wu QW, Yan RF, Li Q, et al (2013). Magnetic resonance image manifestations of the atypical meningioma. Asian Pac J Cancer Prev, 14, 6337-40. https://doi.org/10.7314/APJCP.2013.14.11.6337

Cited by

  1. The impact of postoperative radiation therapy on patterns of failure and survival improvement in patients with intracranial hemangiopericytoma vol.127, pp.1, 2016, https://doi.org/10.1007/s11060-015-2030-8
  2. Intracranial solitary fibrous tumors/hemangiopericytomas: first report of malignant progression pp.0022-3085, 2017, https://doi.org/10.3171/2017.1.JNS162593
  3. Efficacy of adjuvant radiotherapy in the intracranial hemangiopericytoma vol.137, pp.3, 2018, https://doi.org/10.1007/s11060-018-2746-3