Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals

  • Khan, Muhammad (College of Basic Medical Sciences, Dalian Medical University) ;
  • Maryam, Amara (College of Basic Medical Sciences, Dalian Medical University) ;
  • Mehmood, Tahir (College of Basic Medical Sciences, Dalian Medical University) ;
  • Zhang, Yaofang (College of Basic Medical Sciences, Dalian Medical University) ;
  • Ma, Tonghui (College of Basic Medical Sciences, Dalian Medical University)
  • Published : 2015.11.04


Multidrug resistance is a principal mechanism by which tumors become resistant to structurally and functionally unrelated anticancer drugs. Resistance to chemotherapy has been correlated with overexpression of p-glycoprotein (p-gp), a member of the ATP-binding cassette (ABC) superfamily of membrane transporters. P-gp mediates resistance to a broad-spectrum of anticancer drugs including doxorubicin, taxol, and vinca alkaloids by actively expelling the drugs from cells. Use of specific inhibitors/blocker of p-gp in combination with clinically important anticancer drugs has emerged as a new paradigm for overcoming multidrug resistance. The aim of this paper is to review p-gp regulation by dietary nutraceuticals and to correlate this dietary nutraceutical induced-modulation of p-gp with activity of anticancer drugs.


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