Study on Convergence Technique Using the Antimicrobial Resistance and Virulence Genes Analysis in Escherichia coli

대장균의 항균제 내성과 독력 유전자의 분석을 활용한 융합기술연구

  • Han, Jae-Il (Department of Public Health, Graduate School of Dankook University) ;
  • Sung, Hyun-Ho (Department of Clinical Pathology, Dongnam University) ;
  • Park, Chang-Eun (Department of Biomedical Laboratory Science, Namseoul University)
  • 한재일 (단국대학교 일반대학원 보건학과) ;
  • 성현호 (동남보건대학교 임상병리과) ;
  • 박창은 (남서울대학교 임상병리학과)
  • Received : 2015.08.17
  • Accepted : 2015.10.20
  • Published : 2015.10.31


This study was conducted to investigate the characteristics of antibiotic resistant E. coli. its antibiotic susceptibility and pathogenicity were analyzed via molecular convergence technique, for the relationship of antibiotic susceptibility and pathogenicity. The 60 isolated strains consisted of ESBL(+)(8) and ESBL(-)(52) strains. The ESBL(+)(8) strains consisted of 2 strains without a pathogenic gene, stb(3), flich7(1), and flich7-eae(2). The ESBL(-)(52) strains consisted of 26 strains without a pathogenic gene, stx1(3), stb(10), flich7(2), eae(2), stx1-flich7(2), stx1-stb(4), flich7-stb(2), and flich7-stb-eae(1). In conclusion, antibiotic resistance is increasingly, Focused on molecular convergence, showed the correlation of pathogenicity with antibiotic resistance was poor. However, It will be able to find the exact pathogenic factor in the future through convergence technique including the analysis of virulence genes.


Antimicrobial resistence;Convergence technique;Escherichia coli;Extended-spectrum beta-lactamases;Virulence genes


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