DOI QR코드

DOI QR Code

Adult Urological Soft Tissue Sarcomas: A Multicenter Study of the Anatolian Society of Medical Oncology (ASMO)

  • Unal, Olcun Umit (Department of Medical Oncology, Izmir Bozyaka Education and Research Hospital) ;
  • Oztop, Ilhan (Division of Medical Oncology, Department of Internal Medicine, Dokuz Eylul University Medical Faculty) ;
  • Menekse, Serkan (Celal Bayar University Faculty of Medicine) ;
  • Urakci, Zuhat (Dicle University Faculty of Medicine) ;
  • Bozkurt, Oktay (Erciyes University Faculty of Medicine) ;
  • Ozcelik, Melike (Dr. Lutfi Kirdar Education and Research Hospital) ;
  • Gunaydin, Yusuf (Gazi University Faculty of Medicine) ;
  • Yasar, Nurgul (Department of Medical Oncology, Okmeydani Education and Research Hospital) ;
  • Yazilitas, Dogan (Department of Medical Oncology, Ankara Numune Education and Research Hospital) ;
  • Kodaz, Hilmi (Department of Medical Oncology, Trakya University Faculty of Medicine) ;
  • Taskoylu, Burcu Yapar (Department of Medical Oncology, Pamukkale University Faculty of Medicine) ;
  • Aksoy, Asude (Department of Medical Oncology, Firat University Faculty of Medicine) ;
  • Demirci, Umut (Department of Medical Oncology, Dr. Abdurrahman Yurtaslan Education and Research Hospital) ;
  • Araz, Murat (Department of Medical Oncology, Malatya Goverment Hospital) ;
  • Tonyali, Onder (Department of Medical Oncology, Mustafa Kemal University Faculty of Medicine) ;
  • Sevinc, Alper (Department of Medical Oncology, Gaziantep University Faculty of Medicine) ;
  • Yilmaz, Ahmet Ugur (Department of Medical Oncology, Izmir University Faculty of Medicine) ;
  • Benekli, Mustafa (Gazi University Faculty of Medicine)
  • Published : 2015.06.26

Abstract

Objective: To analyze clinicopathological characteristics, prognostic factors and survival rates of the patients with urological soft tissue sarcomas treated and followed up in Turkey. Materials and Methods: For overall survival analyses the Kaplan-Meier method was used. From medical records, nine prognostic factors on overall survival were analysed. Results: For the 53 patients (34 males, 19 females) whose charts were reviewed, the median age was 53 (range 22 to 83) years. Most frequently renal location (n=30; 56.6%) was evident and leiomyosarcoma (n=20, 37.7%) was the most frequently encountered histological type. Median survival time of all patients was 40.3 (95% CI, 14.2-66.3) months. In univariate analysis, male gender, advanced age (${\geq}50years$), metastatic stage, unresectability, grade 3, renal location were determined as worse prognostic factors. In multivariate analysis, metastatic stage, unresectability and grade 3 were determined as indicators of worse prognosis. Conclusions: Urological soft tissue sarcomas are rarely seen tumours in adults. The most important factors in survival are surgical resection, stage of the tumour at onset, grade and location of the tumour, gender and age of the patients.

Keywords

Urologic sarcoma;survival;prognostic factors;Turkey

References

  1. Berkmen F, Celebioglu AS (1997). Adult genitourinary sarcomas: a report of seventeen cases and review of the literature. J Exp Clin Cancer Res, 16, 45-8.
  2. Cheung MR, Kang J, Ouyang D, et al (2014). Socio-economic factors affect the outcome of soft tissue sarcoma: an analysis of SEER data. Asian Pac J Cancer Prev, 15, 25-8. https://doi.org/10.7314/APJCP.2014.15.1.25
  3. Cho SY, Moon KC, Cheong MS, et al (2011). Localized resectable genitourinary sarcoma in adult Korean patients: experiences at a single center. Yonsei Med J, 52, 761-7. https://doi.org/10.3349/ymj.2011.52.5.761
  4. Coindre JM, Terrier P, Bui NB, et al (1996). Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group. J Clin Oncol, 14, 869-77. https://doi.org/10.1200/JCO.1996.14.3.869
  5. Coleman J, Brennan MF, Alektiar K, et al (2003). Adult spermatic cord sarcomas: management and results. Ann Surg Oncol, 10, 669-75. https://doi.org/10.1245/ASO.2003.11.014
  6. Dotan ZA, Tal R, Golijanin D, et al (2006). Adult genitourinary sarcoma: the 25-year Memorial Sloan-Kettering experience. J Urol, 176, 2033-8. https://doi.org/10.1016/j.juro.2006.07.021
  7. Dugandzija T, Mikov MM, Solajic N, et al (2014). Increasing frequency of soft tissue sarcomas in Vojvodina - comparison with the literature. Asian Pac J Cancer Prev, 15, 1011-4. https://doi.org/10.7314/APJCP.2014.15.2.1011
  8. Duman BB, Gunaldi M, Ercolak V, et al (2012). Retrospective analysis of 498 primary soft tissue sarcomas in a single Turkish centre. Asian Pac J Cancer Prev, 13, 4125-8. https://doi.org/10.7314/APJCP.2012.13.8.4125
  9. Froehner M, Lossnitzer A, Manseck A, et al (2000). Favorable long-tem outcome in adult genitourinary low-grade sarcoma. Urol, 56, 373-7. https://doi.org/10.1016/S0090-4295(00)00704-4
  10. Froehner M, Schober RR, Koch R, et al (2013). Adult urologic sarcoma: experience during 2 decades. Urol Oncol, 31, 985-9. https://doi.org/10.1016/j.urolonc.2011.10.002
  11. Froehner M, Koch R, Lossnitzer A, et al (2014). Adult inguinoscrotal sarcomas: outcome analysis of 21 cases, systematic review of the literature and meta-analysis. World J Urol, 32, 445-51. https://doi.org/10.1007/s00345-013-1124-1
  12. Gronchi A, Miceli R, Colombo C, et al (2011). Primary extremity soft tissue sarcomas: outcome improvement over time at a single institution. Ann Oncol, 22, 1675-81. https://doi.org/10.1093/annonc/mdq643
  13. Gross JL, Younes RN, Haddad FJ, et al (2005). Soft-tissue sarcomas of the chest wall: prognostic factors. Chest, 127, 902-8. https://doi.org/10.1378/chest.127.3.902
  14. Izumi K, Mizokami A, Sugimoto K, et al (2010). Role of surgical resection in adult urological soft tissue sarcoma: 25-year experience. Urol Int, 84, 309-14. https://doi.org/10.1159/000288234
  15. Jo VY, Fletcher CDM (2014). WHO classification of soft tissue tumours: an update based on the 2013 (4th). Pathol, 46, 95-104. https://doi.org/10.1097/PAT.0000000000000050
  16. Ko BS, Kim NY, Ryu AJ, et al (2012). A case of paratesticular leiomyosarcoma successfully treated with orchiectomy and chemotherapy. Cancer Res Treat, 44, 210-4. https://doi.org/10.4143/crt.2012.44.3.210
  17. Korkes F, Castro MG, Romero FR, et al (2009). Paratesticular sarcomas in Brazil. Urol Int, 82, 448-52. https://doi.org/10.1159/000218536
  18. Lee G, Lee SY, Seo S, et al (2011). Prognostic factors and clinical outcomes of urological soft tissue sarcomas. Korean J Urol, 52, 669-73. https://doi.org/10.4111/kju.2011.52.10.669
  19. Mondaini N, Palli D, Saieva C, et al (2005). Clinical characteristics and overall survival in genitourinary sarcomas treated with curative intent: a multicenter study. Eur Urol, 47, 468-73. https://doi.org/10.1016/j.eururo.2004.09.013
  20. Neuville A, Chibon F, Coindre JM (2014). Grading of soft tissue sarcomas: from histological to molecular assessment. Pathol, 46, 113-20. https://doi.org/10.1097/PAT.0000000000000048
  21. Ngan R, Wang E, Porter D, et al (2013). Soft-tissue sarcomas in the Asia-Pacific region: a systematic review. Asian Pac J Cancer Prev, 14, 6821-32. https://doi.org/10.7314/APJCP.2013.14.11.6821
  22. Rodriguez D, Preston MA, Barrisford GW, et al (2014). Clinical features of leiomyosarcoma of the urinary bladder: Analysis of 183 cases. Urol Oncol, 32, 958-65. https://doi.org/10.1016/j.urolonc.2014.01.025
  23. Spiess PE, Kassouf W, Steinberg JR, et al (2007). Review of the M.D. Anderson experience in the treatment of bladder sarcoma. Urol Oncol, 25, 38-45. https://doi.org/10.1016/j.urolonc.2006.02.003
  24. Stefanovski PD, Bidoli E, De Paoli A, et al (2002). Prognostic factors in soft tissue sarcomas: a study of 395 patients. Eur J Surg Oncol, 28,153-64. https://doi.org/10.1053/ejso.2001.1242
  25. Stojadinovic A, Leung DH, Hoos A, et al (2002). Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas. Ann Surg, 235, 424-34. https://doi.org/10.1097/00000658-200203000-00015
  26. Vogelzang NJ, Fremgen AM, Guinan PD, et al (1993). Primary renal sarcoma in adults. A natural history and management study by the American Cancer Society, Illinois Division. Cancer, 71, 804-10. https://doi.org/10.1002/1097-0142(19930201)71:3<804::AID-CNCR2820710324>3.0.CO;2-A
  27. Wang X, Xu R, Yan L, et al (2011). Adult renal sarcoma: clinical features and survival in a series of patients treated at a high-volume institution. Urol, 77, 836-41. https://doi.org/10.1016/j.urology.2010.09.028