- Volume 16 Issue 11
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Radiotherapy and Concurrent Chemo-Radiotherapy in Locally Advanced Hypopharyngeal Cancers - A Hospital Registry Based Analysis
- Sharma, Jagannath Dev (Department of Cancer Registry, Epidemiology and Biostatistics, Dr.B Borooah Cancer Institute) ;
- Krishnatreya, Manigreeva (Department of Cancer Registry, Epidemiology and Biostatistics, Dr.B Borooah Cancer Institute) ;
- Das, Ashok Kumar (Department of Head and Neck Oncology, Dr.B Borooah Cancer Institute) ;
- Bhattacharyya, Mouchumee (Department of Radiation Oncology, Dr.B Borooah Cancer Institute) ;
- Hazarika, Munlima (Department of Medical Oncology, Dr.B Borooah Cancer Institute) ;
- Kataki, Amal Chandra (Department of Cancer Registry, Epidemiology and Biostatistics, Dr.B Borooah Cancer Institute) ;
- Baishya, Nizara (Department of Cancer Registry, Epidemiology and Biostatistics, Dr.B Borooah Cancer Institute) ;
- Nandy, Pintu (Department of Cancer Registry, Epidemiology and Biostatistics, Dr.B Borooah Cancer Institute)
- Published : 2015.06.26
Background: The survival of patients with hypopharyngeal cancer is low amongst head and neck cancer cases. The incidence rates of hypopharyngeal cancers in our population are amongst the highest in the world and there are limited data available on the literature on varied responses to first course of treatment with radiotherapy (RT) and concurrent chemo-radiotherapy (CRT) in our population. Materials and Methods: Clinical characteristics and initial responses to treatment in patients who had received radiotherapy and chemo-radiotherapy in a regional cancer center from January 2010 to December 2013 were evaluated. The data were obtained from the hospital cancer registry, and analysis was carried using descriptive statistics. Pearson's chi-square was used to test for differences in the variables and p<0.05 was considered statistically significant. Results: A total of 554 patients were included in the analysis, 411 (74.2%) receiving RT and 143 (25.8%) being given CRT. There was significantly lower number of patients above 70 years with a higher proportion of patients below 50 years who had received CRT (p<0.05). Some 79.3% and 84.6% of patients in the RT and CRT groups respectively presented with a favorable performance status, and in the RT group 240 (58.4%) showed complete response (CR), and in the CRT group 103 (72.0%) showed CR at the first follow-up (p<0.05). Conclusions: Concurrent chemo-radiotherapy gives better short term response to treatment in locally advanced hypopharyngeal cancers.
- Edge S, Byrd DR, Compton CC, et al (2010). AJCC Cancer Staging Manual. 7th ed. Bangalore: Springer-Verlag.
- Eisenhauer EA, Therasse P, Bogaerts J, et al (2009). New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). European J Cancer, 45, 228-47. https://doi.org/10.1016/j.ejca.2008.10.026
- Joo Y, Lee Y, Cho K, et al (2013). Characteristics and prognostic implications of high-risk HPV-associated hypopharyngeal cancers. PLoS ONE, 8, 78718. https://doi.org/10.1371/journal.pone.0078718
- Kim JW, Kim MS, Kim SH, et al (2015). Definitive chemoradiotherapy versus surgery followed by adjuvant radiotherapy in resectable stage III/IV hypopharyngeal cancer. Cancer Res Treat, [Epub ahead of print].
- Krishnatreya M, Rahman T, Kataki AC, et al (2013). Synchronous primary cancers of the head and neck region and upper aero-digestive tract: defining high risk patients. Indian J Cancer, 50, 322-26. https://doi.org/10.4103/0019-509X.123610
- Krishnatreya M, Rahman T, Kataki AC, et al (2014). Pre-treatment performance status and stage at diagnosis in patients with head and neck cancers. Asian Pac J Cancer Prev, 15, 8479-82. https://doi.org/10.7314/APJCP.2014.15.19.8479
- Lasrado S, Moras K, Pinto GW, et al (2014). Role of concomitant chemoradiation in locally advanced head and neck cancers. Asian Pac J Cancer Prev, 15, 4147-52. https://doi.org/10.7314/APJCP.2014.15.10.4147
- Lefebvre JL, Chevalier D, Luboinski B, et al (1996). Larynx preservation in pyriform sinus cancer: preliminary results of a european organization for research and treatment of cancer phase III trial. EORTC head and neck cancer cooperative Group. J Natl Cancer Inst, 88, 890-9. https://doi.org/10.1093/jnci/88.13.890
- National Cancer Registry Programme (2013).Three-year report of population based cancer registries: 2009-2011. NCDIR-ICMR, Bangalore.
- Shaughnessy JN, Farghaly H, Wilson L, et al (2014). HPV: a factor in organ preservation for locally advanced larynx and hypopharynx cancer? Am J Otolaryngol, 35, 19-24. https://doi.org/10.1016/j.amjoto.2013.08.006
- Takes RP, Strojan P, Silver CE, et al (2012). Current trends in initial management of hypopharyngeal cancer: the declining use of open surgery. Head Neck, 34, 270-81. https://doi.org/10.1002/hed.21613
- VanderWalde NA, Meyer AM, Deal AM, et al (2014). Effectiveness of chemoradiation for head and neck cancer in an older patient population. Int J Radiat Oncol Biol Phys, 89, 30-7. https://doi.org/10.1016/j.ijrobp.2014.01.053
- Wong YF,Yusof MM, Wan Ishak WZ, et al (2015). Treatment outcome for head and neck squamous cell carcinoma in a developing country: university Malaya medical centre, Malaysia from 2003-2010. Asian Pac J Cancer Prev, 16, 2903-8. https://doi.org/10.7314/APJCP.2015.16.7.2903