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Aberrant Methylation of RASSF1A gene Contribute to the Risk of Renal Cell Carcinoma: a Meta-Analysis

  • Yu, Gan-Shen (Department of Urology, The First Affiliated Hospital of JINAN University) ;
  • Lai, Cai-Yong (Department of Urology, The First Affiliated Hospital of JINAN University) ;
  • Xu, Yin (Department of Urology, The First Affiliated Hospital of JINAN University) ;
  • Bu, Chen-Feng (Department of Urology, The First Affiliated Hospital of JINAN University) ;
  • Su, Ze-Xuan (Department of Urology, The First Affiliated Hospital of JINAN University)
  • Published : 2015.06.26

Abstract

The aim of this study was to assess the diagnostic value of RASSF1A methylation in renal cell carcinoma. Systematically search were performed using the Pubmed, ProQest and Web of Science for all articles on the association between RASSF1A methylation and renal cell carcinoma before 15 April 2015. After the filtration, 13 studies involving 677 cases and 497 controls met our criteria. Our meta-analysis suggested that hypermethylation of RASSF1A gene was associated with the increased risk of RCC(OR:4.14, 95%CI:1.06-16.1). Stratified analyses showed a similar risk in qualitative detection method(OR:28.4, 95%CI:10.2-79.6), body fluid sample(OR:12.8, 95%CI:5.35-30.8), and American(OR:10.5, 95%CI:1.97-55.9). Our result identified that RASSF1A methylation had a strong potential in prediction the risk of Renal cell carcinoma.

Keywords

RAS association domain family 1A;renal cell carcinoma;DNA methylation;meta-analysis

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