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Relations of Serum Visfatin and Resistin Levels with Endometrial Cancer and Factors Associated with its Prognosis

  • Ilhan, Tolgay Tuyan (Gynecologic Oncology, Medical Faculty, University of Selcuk) ;
  • Kebapcilar, Aysegul (Gynecology, Medical Faculty, University of Selcuk) ;
  • Yilmaz, Setenay Arzu (Gynecology, Medical Faculty, University of Selcuk) ;
  • Ilhan, Turkan (Beyhekim State Hospital) ;
  • Kerimoglu, Ozlem Secilmis (Gynecology, Medical Faculty, University of Selcuk) ;
  • Pekin, Aybuke Tazegul (Gynecology, Medical Faculty, University of Selcuk) ;
  • Akyurek, Fikret (Biochemistry, Medical Faculty, University of Selcuk) ;
  • Unlu, Ali (Biochemistry, Medical Faculty, University of Selcuk) ;
  • Celik, Cetin (Gynecologic Oncology, Medical Faculty, University of Selcuk)
  • Published : 2015.06.26

Abstract

Background: The aims of this study were compare the serum visfatin and resistin levels between endometrial cancer (EC) patients and controls and evaluate their power to predict prognosis. Materials and Methods: This prospective study was conducted between March 2013 to June 2014 on the Gynecologic Oncology Department of the University of Selcuk, Konya, Turkey. A total of 42 EC patients and 42 controls were included and assessed for differences in serum visfatin and resistin levels, along with prognostic factors. Results: Endometrial cancer patients had significantly higher visfatin levels than control s (p: 0.011), associated with deep myometrial invasion (p: 0.019). In contrast the serum level of resistin did not significantly differ between EC patients and controls (p: 0.362). However, high resistin level in EC patients was associated with increase lymph node metastasis (p: 0.009). On logistic regression analysis, we found that serum visfatin elevation was associated with risk of myometrial invasion (OR: 1,091; 95%CI: 1.021-1.166; p: 0.010) and serum resistin with risk of lymph node metastasis (OR: 1.018; 95%CI: 1.000-1.035; p: 0.046). For myometrial invasion prediction, a serum visfatin level greater than 26.8 ng/mL demonstrated a sensitivity and specificity of 66.6 % and 96.4%, respectively. For lymph node metastasis prediction, the best cut-off for serum resistin level was 599ng/mL. A serum resistin level greater than this demonstrated a sensitivity and specificity of 87.5% and 77.1%, respectively. Conclusions: Our data suggest that serum visfatin is elevated in patients with EC and serum visfatin and resistin levels could be used to predict the risk of advance stage lesions.

Keywords

Visfatin;resistin;endometrial cancer;adipocytokine

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