DOI QR코드

DOI QR Code

Comparative Study of Carcinoembryonic Antigen Tumor Marker in Stomach and Colon Cancer Patients in Khyber Pakhtunkhwa

  • Ahmad, Bashir (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Gul, Bushra (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Ali, Sajid (Department of Biotechnology, Abdul Wali Khan University Mardan) ;
  • Bashir, Shumaila (Department of Pharmacy, University of Peshawar) ;
  • Mahmood, Nourin (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Ahmad, Jamshed (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Nawaz, Seema (Centre for Biotechnology and Microbiology, University of Peshawar)
  • Published : 2015.06.26

Abstract

Background: Due to the increase in morbidity and mortality rate, cancer has become an alarming threat to the human population worldwide. Since cancer is a progressive disorder, timely diagnosis would be helpful to prevent/stop cancer from progressing to severe stage. In Khyber Pakhtunkhwa, Pakistan, most of the time, tumors are diagnosed with endoscopy and biopsy; therefore rare studies exist regarding the diagnosis of gastrointestinal (GIT) carcinomas based on tumor markers, especially CEA. Objectives: This study made a comparative analysis of CEA in admitted hospitalized stomach and colon cancer patients diagnosed as GIT with biopsy. Materials and Methods: In this study, a total of 66 cases were included. The level of CEA was determined in the blood of these patients using ELISA technique. Results: Out of 66 patients, the level of CEA was high in 59.1% of the total, 60.7% in colon cancer patients and 57.9 % in stomach cancer patients. Moreover, the incidence of colorectal and stomach cancer was greater in males as compared to females. Patients were more of the age group of 40-60 and the level of CEA was comparatively higher in patients (51.5%) with histology which was moderately differentiated, than patients with well differentiated and poorly differentiated tumor histology. Conclusions: CEA level was high in more than 50% of the total patients. Moreover, CEA exhibited higher sensitivity for colon than stomach cancer.

Keywords

Gastrointestinal tumors;CEA;Khyber Pakhtunkhwa;enzyme linked immunosorbant assay

References

  1. Hanahan D, Weinberg RA (2000). The hall marks of Cancer. Cell, 100, 57-70. https://doi.org/10.1016/S0092-8674(00)81683-9
  2. Chaudhary AM, Ahmed MZ, Chaudhary, MS (2010). Comparison of CEA and CA 19-9 with CA 72-4 in patients with upper Gastrointestinal carcinomas in local population. Biomedica, 26, 16-19.
  3. Sisik A, Kaya M, Bas G, et al (2013) CEA and CA 19-9 are still valuable markers for the prognosis of colorectal and gastric cancer patients. Asian Pac J Cancer Prev, 14, 4289-94. https://doi.org/10.7314/APJCP.2013.14.7.4289
  4. Gul A, Sharif G, Alam SI, et al (2012). Clinical presentations of colorectal carcinoma inpatients below 40 years of age presenting to a tertiary care level hospital. J Med Sci, 20, 67-70.
  5. Al- Shuneigat JM, Mahgoub SS, Huq F (2011). Colorectal carcinoma: nucleosomes, carcinoembryonic antigen and CA 19-9 as apoptotic markers; a comparative study. J Medical Sci, 18, 18-50.
  6. Hadi NI, Kafil N, Waseem B, et al (2009). Incidence of colorectal carcinoma is there a "shift to the right. Pakistan J Pharmacology, 26, 1-5.
  7. Oue N, Hamai Y, Mitani Y, et al (2004). Metastasis, and carcinogenesis by serial analysis of gene of genes and tags potentially involved in invasion, gene expression profile of gastric carcinoma: identification expression. Cancer Res, 64, 2397-2405. https://doi.org/10.1158/0008-5472.CAN-03-3514
  8. Al-Saady RK, Al-Tai WF, Himdan TA (2012). Determination of cancer antigen CA15-3 and carcino embryonic antigen CEA concentration as tumor markers in patients with stomach and colorectal cancers. J Facul Med Baghdad, 54, 256-258.
  9. Attaullah AM, Al-Ghawalby NA, Abdul aziz AF, et al (2006). Clinical value of Serum CEA, CA19-9, CA 242 and AFP in Diagnosis of Gastrointestinal Tract Cancer. Int J Cancer Res, 2, 50-6. https://doi.org/10.3923/ijcr.2006.50.56
  10. Dbouk HA, Tawil A, Nasr F, et al (2007). Significance of CEA and VEGF as Diagnostic Markers of Colorectal Cancer in Lebanese Patients. Open Clin Cancer J, 1, 1-5. https://doi.org/10.2174/1874189400701010001
  11. Ghoraishian SM, Jalali BA, Mozayan MR (2006). Serum Level of CA15.3 and CEA in women affected with breast cancer. World J Med Sci, 1, 48-51.
  12. Tan E, Gouvas N, Nicholls RJ, et al (2009). Diagnostic precision of carcinoembryonic antigen in the detection of recurrence of colorectal cancer. Surgical Oncol, 18, 15-24. https://doi.org/10.1016/j.suronc.2008.05.008
  13. Liu X, Cai H, Wang Y (2012). Prognostic significance of tumor markers in T4a gastric cancer World. World J Surg Oncol, 10, 1-9. https://doi.org/10.1186/1477-7819-10-1
  14. Rezamansourian A, Ghaemi E (2011). The Prevalence of Elevated Carcinoembroynic Antigen at Gorgan South-East Caspian Sea of Northern Iran. J Clin Diagnostic Res, 5, 74-77.
  15. Moldrich G, Lange P, Strick H (2010). Carcinoembryonic Antigen in the CSF of Cancer Patients - the value of intrathecal synthesis and correlation with IgA-diffusion dynamics. Acta Neural Belg, 110, 314-320.
  16. Abdel-Gawad IA, Hassanein HMR, Bahgat NA, et al (2008). Study of endothelin-1 and vascular endothelial growth factor in patients with cancer colon. J Egypt Natl Cancer Inst, 20, 216-23.
  17. Wang WS, Lin JK, Chion TJ, Lio JH, Fan FS, Yen CC et al (1999). Preoperative carcinoembryonic antigen level as an independent prognostic factor in colorectal cancer: Taiwan Experience. Japanese J Clin Oncol, 30, 12-16.
  18. Herszenyi L, Farinati F, Cardin R, et al (2008). Tumor marker utility and prognostic relevance of cathepsinB, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. BioMed central Cancer. doi:10.1186/1471-2407-8-194. https://doi.org/10.1186/1471-2407-8-194
  19. Jemal A, Bray F, Ferlay J, et al (2011). Global cancer statistics. CA: Cancer J Clin, 61, 69-0. https://doi.org/10.3322/caac.20107
  20. Haggar FA, Boushey RP (2009). Colorectal cancer epidemiology: incidence, mortality, survival, and risk factors. Clin Colon Rectal Surg, 22, 191-7. https://doi.org/10.1055/s-0029-1242458
  21. Wang X Q, Terry P D, Yan H (2009). Review of salt consumption and stomach cancer risk: epidemiological and biological evidence. World J Gastroenterol, 15, 2204-13. https://doi.org/10.3748/wjg.15.2204
  22. Ahmad Z, Idrees R, Ahmed R, et al (2005). ColorectalCarcinoma, Extent and Spread in our Population. Resection Specimens give ValuableInformation. J Pakistan Med Associat, 55, 483-5.
  23. Khan J S, Aftab M, Sheryar M, et al (2011). Malignancy, a disease of old age: an analysis of 2520 cases. Ann Pakistan I Med Sci, 7,18-21.
  24. Laishram RS, Kaiho N, Shmray R, et al (2010). Histopathological evaluation of colorectal carcinomas status in Manipur, India. Int J Pathol, 8, 5-8.
  25. Mcgrath SC, Ebert M, Rocken C (2007). Gastric adenocarcinoma: epidemiology, pathology and pathogenesis. Cancer Therapy, 5, 877-894.
  26. Shaikh AJ, Raza S, Sheikh AA, et al (2009). Demographics, pathologic patterns and long-term survival in operable colon cancers: localexperience in Pakistan. Asian Pac J Cancer Prev, 10, 361-364.
  27. Fazeli MS, Adel MG, Lebaschi AH (2007). Colorectal carcinoma: a retrospective, descriptive study of age, gender, subsite, stage, and differentiation in Iran from 1995 to 2001 as observed in Tehran University. Disease Colon Rectum, 50, 990-5. https://doi.org/10.1007/s10350-007-0248-z
  28. Suwanagool P, Fujimori T, Maeda S (1990). Value of tissue carcinoembryonic antigen in patients with colorectal carcinoma. Asian Pac J Allergy Im, 8, 33-37.
  29. Carpelan HMA, Haglund CH, Roberts PJ (1996). Differences in serum tumor markers between colon and rectal cancer. Comparison of CA 242 and carcinoembryonic antigen. Disease Colon Rectum, 39, 799-805. https://doi.org/10.1007/BF02054447
  30. Bagaria B, Sood S, Sharma R, et al (2013). Comparative study of CEA and CA19-9 in esophageal, gastric and colon cancers individually and in combination (ROC curve analysis). Cancer Biol Medicine, 10, 148-157.
  31. Tocchi A, Costa G, Lepre L, et al (1998). The role of serum and gastric juice levels of carcinoembryonic antigen, CA19.9 and CA72.4 in patients with gastric cancer. J Cancer Res Clin Oncol, 124, 450-455. https://doi.org/10.1007/s004320050198
  32. Kochi M, Fujii M, Kanamori N, et al (2000). Evaluation of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. Gastric Cancer, 3, 177-186. https://doi.org/10.1007/PL00011715

Cited by

  1. Deterministic Role of CEA and MSI Status in Predicting Outcome of CRC Patients: a Perspective Study Amongst Hospital Attending Eastern Indian Populations vol.8, pp.4, 2017, https://doi.org/10.1007/s13193-017-0651-4