- Volume 16 Issue 11
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Comparative Study of Carcinoembryonic Antigen Tumor Marker in Stomach and Colon Cancer Patients in Khyber Pakhtunkhwa
- Ahmad, Bashir (Centre for Biotechnology and Microbiology, University of Peshawar) ;
- Gul, Bushra (Centre for Biotechnology and Microbiology, University of Peshawar) ;
- Ali, Sajid (Department of Biotechnology, Abdul Wali Khan University Mardan) ;
- Bashir, Shumaila (Department of Pharmacy, University of Peshawar) ;
- Mahmood, Nourin (Centre for Biotechnology and Microbiology, University of Peshawar) ;
- Ahmad, Jamshed (Centre for Biotechnology and Microbiology, University of Peshawar) ;
- Nawaz, Seema (Centre for Biotechnology and Microbiology, University of Peshawar)
- Published : 2015.06.26
Background: Due to the increase in morbidity and mortality rate, cancer has become an alarming threat to the human population worldwide. Since cancer is a progressive disorder, timely diagnosis would be helpful to prevent/stop cancer from progressing to severe stage. In Khyber Pakhtunkhwa, Pakistan, most of the time, tumors are diagnosed with endoscopy and biopsy; therefore rare studies exist regarding the diagnosis of gastrointestinal (GIT) carcinomas based on tumor markers, especially CEA. Objectives: This study made a comparative analysis of CEA in admitted hospitalized stomach and colon cancer patients diagnosed as GIT with biopsy. Materials and Methods: In this study, a total of 66 cases were included. The level of CEA was determined in the blood of these patients using ELISA technique. Results: Out of 66 patients, the level of CEA was high in 59.1% of the total, 60.7% in colon cancer patients and 57.9 % in stomach cancer patients. Moreover, the incidence of colorectal and stomach cancer was greater in males as compared to females. Patients were more of the age group of 40-60 and the level of CEA was comparatively higher in patients (51.5%) with histology which was moderately differentiated, than patients with well differentiated and poorly differentiated tumor histology. Conclusions: CEA level was high in more than 50% of the total patients. Moreover, CEA exhibited higher sensitivity for colon than stomach cancer.
Gastrointestinal tumors;CEA;Khyber Pakhtunkhwa;enzyme linked immunosorbant assay
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