Comparative Study of Carcinoembryonic Antigen Tumor Marker in Stomach and Colon Cancer Patients in Khyber Pakhtunkhwa

  • Ahmad, Bashir (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Gul, Bushra (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Ali, Sajid (Department of Biotechnology, Abdul Wali Khan University Mardan) ;
  • Bashir, Shumaila (Department of Pharmacy, University of Peshawar) ;
  • Mahmood, Nourin (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Ahmad, Jamshed (Centre for Biotechnology and Microbiology, University of Peshawar) ;
  • Nawaz, Seema (Centre for Biotechnology and Microbiology, University of Peshawar)
  • Published : 2015.06.26


Background: Due to the increase in morbidity and mortality rate, cancer has become an alarming threat to the human population worldwide. Since cancer is a progressive disorder, timely diagnosis would be helpful to prevent/stop cancer from progressing to severe stage. In Khyber Pakhtunkhwa, Pakistan, most of the time, tumors are diagnosed with endoscopy and biopsy; therefore rare studies exist regarding the diagnosis of gastrointestinal (GIT) carcinomas based on tumor markers, especially CEA. Objectives: This study made a comparative analysis of CEA in admitted hospitalized stomach and colon cancer patients diagnosed as GIT with biopsy. Materials and Methods: In this study, a total of 66 cases were included. The level of CEA was determined in the blood of these patients using ELISA technique. Results: Out of 66 patients, the level of CEA was high in 59.1% of the total, 60.7% in colon cancer patients and 57.9 % in stomach cancer patients. Moreover, the incidence of colorectal and stomach cancer was greater in males as compared to females. Patients were more of the age group of 40-60 and the level of CEA was comparatively higher in patients (51.5%) with histology which was moderately differentiated, than patients with well differentiated and poorly differentiated tumor histology. Conclusions: CEA level was high in more than 50% of the total patients. Moreover, CEA exhibited higher sensitivity for colon than stomach cancer.


Gastrointestinal tumors;CEA;Khyber Pakhtunkhwa;enzyme linked immunosorbant assay


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