Peptide H reduces Il-6 expression in human breast cancer MDA-MB-231 cells

인간유방암 MDA-MB-231세포에서 peptide H에 의한 TNFα 발현 억제

  • Sung, Dae Il (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University) ;
  • Park, Jameon (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University) ;
  • Kang, Choong Kyung (Department of Nanobiotronics, Bioconvergence Lab, Hoseo University) ;
  • Kim, Han Bok (Department of Biotechnology, The Research Institute for Basic Sciences, Hoseo University)
  • 성대일 (호서대학교 생명공학과 기초과학연구소) ;
  • 박잠언 (호서대학교 생명공학과 기초과학연구소) ;
  • 강충경 (호서대학교 나노바이오트로닉스학과 바이오융합연구소) ;
  • 김한복 (호서대학교 생명공학과 기초과학연구소)
  • Received : 2015.07.28
  • Accepted : 2015.09.12
  • Published : 2015.09.30


Chungkookjang (fermented soybeans) contains diverse peptides. Human breast cancer MDA-MB-231 cells were treated with peptide H derived from Chungkookjang, and $TNF{\alpha}$ expression in the cells was conspicuously repressed, suggesting peptide H's regulation of IL6 since IL6 is induced by $TNF{\alpha}$. The structure of peptide H was different from those of glucocorticoid and dexamethasone, suggesting different mechanisms of $TNF{\alpha}$ expression suppression. Peptide H which reduces $TNF{\alpha}$ expression can be developed as drugs for cancer, rheumatoid arthritis and Crohn's disease, after more investigation.


breast cancer;inflammation;peptide;$TNF{\alpha}$


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