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Organ Weights and Splenocytic Apoptosis in γ-irradiated Korean Dark-Striped Field Mice, Apodemus Agrarius Coreae

방사선 조사된 국내 야생 등줄쥐 (Apodemus agrarius coreae) 장기무게 및 비장세포 세포고사

  • Joo, Hyunjin (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co. Ltd.) ;
  • Choi, Hoon (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co. Ltd.) ;
  • Yang, Kwang-hee (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co. Ltd.) ;
  • Keum, Dong-kwon (Nuclear Environment Research Division, Korea Atomic Energy Research Institute) ;
  • Kim, Hee sun (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co. Ltd.)
  • 주현진 (한국수력원자력(주) 방사선보건원) ;
  • 최훈 (한국수력원자력(주) 방사선보건원) ;
  • 양광희 (한국수력원자력(주) 방사선보건원) ;
  • 금동권 (한국원자력연구원 원자력환경연구부) ;
  • 김희선 (한국수력원자력(주) 방사선보건원)
  • Received : 2015.04.30
  • Accepted : 2015.08.17
  • Published : 2015.09.30

Abstract

The present investigation was planned to estimate potential possibility of striped field mice, Apodemus agrarius coreae (A. a. coreae), as a biological dosimeter in radio-environmental ecology. We bred captured wild A. a. coreae at laboratory and classified taxonomically based on external, cranial and tooth characters. Organ weights and splenocytic apoptosis were observed in order to establish a basic data on radiation biology of A. a. coreae (male, 40 weeks old). The biological effects was observed at 24hrs following irradiation (doses : 0, 0.5, 1, 2 Gy, dose rate : $0.8Gymin^{-1}$, $^{137}Cs$). Only thymus weights was significantly decreased. Splenocytic apoptosis was increased after irradiation. But splenocytic apoptosis was decreased in 0.5 Gy ${\gamma}$-irradiated mice compared to those of 0, 1, 2 Gy (P < 0.05). These data suggested that events in thymus and spleen of Korean dark-striped field mice, A. a. coreae THOMAS, could be a potential radio-biological indicator in human environments.

Acknowledgement

Supported by : 한국연구재단

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