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Analysis of Relationships Between Prethrombotic States and Cervical Cancer

  • Sun, You-Hong (Department of Gynaecology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Cui, Lin (Department of Oncology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Chen, Jue (Department of Oncology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Wang, Min (Department of Gynaecology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Liu, Jian-Jun (Department of Oncology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Liu, Xing-Xiang (Department of Oncology, Taizhou Second People's Hospital, the Affiliated Hospital of Yangzhou University) ;
  • Huang, Xin-En (Department of Chemotherapy, Affiliated Jiangsu Cancer Hospital of Nanjing Medical University & Jiangsu Institute of Cancer Research)
  • Published : 2015.09.02

Abstract

Objective: To analyze the relationship between a prethrombotic state and the occurrence of thrombosis, as well as survival time for patients with cervical cancer. Methods: Patients with first diagnosis of cervical cancer were subgrouped according to FIGO staging, and two D-dimer levels were assessed. According to the results, patients are divided into an observation group (abnormal) and control group (normal). Results: For 106 patients with cervical cancer, 38 with abnormal D-dimer, the abnormal rate is 35.9%, of which stage I accounted for 6.5%, stage II 38.5%, stage III 50%, and stage IV 61.1% (p=0.013); The level of D-dimers in stageI wass $0.87{\pm}0.68ug/ml$, while in stage II it was $1.50{\pm}1.35ug/ml$, stage III $2.60{\pm}1.86ug/ml$ and stage IV $18.6{\pm}53.4ug/ml$ (P=0.031); after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control group it was 2.94% (p <0.01). In the observation group, survival time was $15.1{\pm}5.8$ months, while for control group it was $21.0{\pm}5.4$ months, the difference between two groups being highly significant (p=0.000). Conclusion: There is a direct correlation between prethrombotic state and the grade malignancy of cervical cancer. The level is positively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic state could be used to predict the prognosis for patients with cervical cancer.

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