- Volume 16 Issue 14
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Prognostic Value of Chemotherapy-Induced Amenorrhea in Breast Cancer: a Meta-Analysis
- Zha, Quan-Bin (Department of Oncology, Jintan Hospital Affiliated to Jiangsu University) ;
- Tang, Jin-Hai (Department of General Surgery, Jiangsu Cancer Hospital) ;
- Li, Xiu-Juan (Department of General Surgery, Jiangsu Cancer Hospital) ;
- Xia, Lei (Department of Pathology, Jiangsu Cancer Hospital) ;
- Zhang, Zhe (Department of Pathology, Jiangsu Cancer Hospital) ;
- Ren, Zhao-Jun (Department of Pathology, Jiangsu Cancer Hospital) ;
- Xu, Xin-Yu (Department of Pathology, Jiangsu Cancer Hospital)
- Published : 2015.09.02
Background: There is still a great deal of controversy with regard to the prognostic role of chemotherapy-induced amenorrhea (CIA) in breast cancer patients. To confirm whether CIA can serve as a useful factor in predicting clinical effects of systemic adjuvant chemotherapy, we performed this meta-analysis. Materials and Methods: Relevant studies were identified using PubMed, and Embase databases. Eligible study results were pooled and summary hazard ratios (HRs) with corresponding confidence intervals (CIs) were calculated. Subgroup analyses and an assessment of publication bias were also conducted. Results: A total of 8,333 patients from 11 published studies were identified through searching the databases. The pooled HRs for disease-free survival (DFS) suggested that CIA was associated with a significant reduction in the risk of recurrence, especially in patients with hormone receptor-positive lesions (overall HR=0.65, 95%CI 0.53-0.80,
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